Schoenberger J A
Control Clin Trials. 1987 Dec;8(4 Suppl):74S-78S. doi: 10.1016/0197-2456(87)90009-2.
The Aspirin Myocardial Infarction Study (AMIS) was a randomized double-masked trial of the efficacy of aspirin in the secondary prevention of coronary heart disease. Thirty clinics randomized 4524 post-myocardial infarction patients to aspirin or placebo treatment. Recruitment was achieved in 14 months as planned, but nearly half of the patients were not randomized until the last 5 months of the recruitment period. Direct public appeal, self-referral, and review of hospital records provided 75% of the participants. Physician referral accounted for only 15%. The demographic characteristics of the sample revealed two thirds to be 50 years of age or older, 90% to be male, and 90% to be white.
阿司匹林心肌梗死研究（AMIS）是一项关于阿司匹林在冠心病二级预防中疗效的随机双盲试验。30个诊所将4524名心肌梗死后患者随机分为阿司匹林治疗组或安慰剂治疗组。招募工作按计划在14个月内完成，但近一半的患者直到招募期的最后5个月才被随机分组。直接向公众呼吁、患者自荐以及查阅医院记录提供了75%的参与者。医生转诊仅占15%。样本的人口统计学特征显示，三分之二的患者年龄在50岁及以上，90%为男性，90%为白人。
