The Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia,
The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia,
Fetal Diagn Ther. 2021;48(7):493-503. doi: 10.1159/000517151. Epub 2021 Aug 17.
Iatrogenic preterm premature rupture of the fetal membranes (iPPROM) remains the Achilles' heel of keyhole fetal surgery (fetoscopy) despite significant efforts in preclinical models to develop new therapies. This limited success is partially due to incomplete understanding why the fetal membranes rupture early after fetoscopy and notable differences in membrane physiology between humans and domestic species. In this review, we summarize aspects of fetoscopy that may contribute to iPPROM, the previous efforts to develop new therapies, and limitations of preclinical models commonly used in fetal membrane research.
尽管在临床前模型中做出了巨大努力来开发新疗法，但医源性早产胎膜早破（iPPROM）仍然是锁孔胎儿手术（胎儿镜）的阿喀琉斯之踵。这种有限的成功部分归因于对为什么胎儿镜后胎膜过早破裂以及人与家畜之间膜生理学的显著差异的理解不完整。在这篇综述中，我们总结了可能导致 iPPROM 的胎儿镜的各个方面、以前开发新疗法的努力以及在胎儿膜研究中常用的临床前模型的局限性。
