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Laser Treatment of Traumatic Scars and Contractures: 2020 International Consensus Recommendations.激光治疗创伤性瘢痕和挛缩:2020 年国际共识建议。
Lasers Surg Med. 2020 Feb;52(2):96-116. doi: 10.1002/lsm.23201. Epub 2019 Dec 9.
2
Randomized, Controlled Early Intervention of Dynamic Mode Fractional Ablative CO Laser on Acute Burn Injuries for Prevention of Pathological Scarring.随机、对照、早期干预的动态模式分数消融 CO2 激光治疗急性烧伤预防病理性瘢痕。
Lasers Surg Med. 2020 Feb;52(2):117-124. doi: 10.1002/lsm.23170. Epub 2019 Oct 20.
3
Laser Therapy of Traumatic and Surgical Scars and an Algorithm for Their Treatment.激光治疗外伤性和手术性瘢痕及治疗方案
Lasers Surg Med. 2020 Feb;52(2):125-136. doi: 10.1002/lsm.23171. Epub 2019 Oct 17.
4
Ablative fractional resurfacing with laser-facilitated steroid delivery for burn scar management: Does the depth of laser penetration matter?激光辅助类固醇递送的消融性分数性表面重建术用于烧伤瘢痕管理:激光穿透深度是否重要?
Lasers Surg Med. 2020 Feb;52(2):149-158. doi: 10.1002/lsm.23166. Epub 2019 Sep 30.
5
Laser Therapy for Pediatric Burn Scars: Focusing on a Combined Treatment Approach.小儿烧伤瘢痕的激光治疗:聚焦联合治疗方法
J Burn Care Res. 2018 Apr 20;39(3):457-462. doi: 10.1093/jbcr/irx008.
6
Early laser intervention to reduce scar formation - a systematic review.早期激光干预以减少瘢痕形成 - 系统评价。
J Eur Acad Dermatol Venereol. 2018 Jul;32(7):1099-1110. doi: 10.1111/jdv.14856. Epub 2018 Mar 13.
7
Efficacy of Fractional Carbon Dioxide Laser in the Treatment of Mature Burn Scars: A Clinical, Histopathological, and Histochemical Study.分次二氧化碳激光治疗成熟烧伤瘢痕的疗效:一项临床、组织病理学和组织化学研究。
J Clin Aesthet Dermatol. 2017 Dec;10(12):36-43. Epub 2017 Dec 1.
8
Comparison of the effectiveness of pulsed dye laser vs pulsed dye laser combined with ultrapulse fractional CO laser in the treatment of immature red hypertrophic scars.脉冲染料激光与脉冲染料激光联合超脉冲分数CO2激光治疗未成熟红色增生性瘢痕的疗效比较。
J Cosmet Dermatol. 2018 Feb;17(1):54-60. doi: 10.1111/jocd.12487.
9
Experimental Study of 5-fluorouracil Encapsulated Ethosomes Combined with CO2 Fractional Laser to Treat Hypertrophic Scar.5-氟尿嘧啶包封的醇质体联合二氧化碳点阵激光治疗增生性瘢痕的实验研究
Nanoscale Res Lett. 2018 Jan 18;13(1):26. doi: 10.1186/s11671-017-2425-x.
10
In-Vivo Histological Analysis of a Fractional CO2 Laser System Intended for Treatment of Soft Tissue.用于软组织治疗的二氧化碳分数激光系统的体内组织学分析
J Drugs Dermatol. 2017 Nov 1;16(11):1085-1090.

[剥脱性二氧化碳激光治疗挛缩性瘢痕的临床疗效]

[Clinical effect of fractional carbon dioxide laser in the treatment of contracture scars].

作者信息

Xi W J, Zhang Z, Li J, Su W J, Li H, Pu Z M, Zhang Y, Feng S Q, Zhang Y X

机构信息

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

出版信息

Zhonghua Shao Shang Za Zhi. 2021 Aug 20;37(8):711-717. doi: 10.3760/cma.j.cn501120-20210624-00225.

DOI:10.3760/cma.j.cn501120-20210624-00225
PMID:34404161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11917297/
Abstract

To explore the clinical effect of the fractional carbon dioxide laser in the treatment of contracture scars. A retrospective before-after self-control study was conducted. From December 2016 to April 2021, 16 patients (7 males and 9 females, aged 3-49 years) with contracture scars causing impaired function of the adjacent joint were admitted to Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Eighteen joint scars of 16 patients were treated with fractional carbon dioxide laser every 2-3 months until the joint retained its normal range of motion or the effect plateaued. The treatment times of each patient were recorded. Before the first treatment and 6 months after the last treatment, the ranges of motion of the affected joint were measured in each patient, and the difference was calculated, meanwhile, the Vancouver Scar Scale (VSS) was used to evaluate the scar of each patient. In the treatment of 1 joint scar in each of 6 patients (totally 6 times of treatments), the ranges of motion of the affected joint before the current treatment, immediately after the treatment, and at the first follow-up after the treatment were documented, and the differences between the ranges before and immediately after the treatment as well as between the ranges before and at the first follow-up after the treatment were calculated. Adverse effects after the treatment in the treatment area were documented. At the last follow-up, a self-made questionnaire was used to collect the implementation status of the physical therapy and other scar management modalities during the treatment interval and follow-up period. Data were statistically analyzed with Wilcoxon rank sum test. Eighteen joint scars in 16 patients received 2 (1, 3) times of fractional carbon dioxide laser treatment. The range of motion of the affected joint of 16 patients 6 months after the last treatment was 56.5 (39.0, 128.8)°, notably higher than 38.4 (22.9, 116.3)° before the first treatment (=-3.724, <0.01), showing a remarkable improvement by 17.4 (8.0, 24.1)°. The vascular distribution, softness, and thickness scores, and total score in VSS scoring of scars of 16 patients 6 months after the last treatment were significantly lower than those before the first treatment (=-2.989, -3.762, -2.814, -3.739, <0.01), with the most obvious improvement in softness. In 6 times of treatments, the range of motion of the affected joint immediately after treatment and at the first follow-up of (2.5±0.6) months after treatment were 156.2 (148.0, 164.2)° and 160.2 (156.7, 166.4)°, both notably higher than 151.4 (145.7, 155.3)° before treatment (=-2.201, -2.201, <0.05), showing a remarkable improvement by 9.1 (4.4, 13.0)° and 13.1 (8.0, 15.7)°, respectively. No adverse effects such as blisters, infection, or hypertrophic scar formation were observed in the treatment area of 16 patients after treatment. Most patients adopted physical therapy, compression, silicone gel or sheets, and braces during the treatment interval and follow-up period. The fractional carbon dioxide laser can soften the scar and increase the range of motion of the affected joint, which is suitable for the clinical treatment of mild contracture scars.

摘要

探讨分次二氧化碳激光治疗挛缩性瘢痕的临床效果。进行回顾性自身前后对照研究。2016年12月至2021年4月,上海交通大学医学院附属第九人民医院收治16例(男7例,女9例,年龄3 - 49岁)因挛缩性瘢痕导致相邻关节功能障碍的患者。对16例患者的18处关节瘢痕每2 - 3个月进行一次分次二氧化碳激光治疗,直至关节保持正常活动范围或效果稳定。记录每位患者的治疗次数。在首次治疗前及末次治疗后6个月,测量每位患者患侧关节的活动范围并计算差值,同时采用温哥华瘢痕量表(VSS)评估每位患者的瘢痕情况。对6例患者各1处关节瘢痕(共6次治疗)记录当前治疗前、治疗后即刻及治疗后首次随访时患侧关节的活动范围,计算治疗前与治疗后即刻以及治疗前与治疗后首次随访时活动范围的差值。记录治疗区域治疗后的不良反应。在末次随访时,采用自制问卷收集治疗期间及随访期物理治疗及其他瘢痕管理方式的实施情况。采用Wilcoxon秩和检验进行统计学分析。16例患者的18处关节瘢痕接受了2(1,3)次分次二氧化碳激光治疗。16例患者末次治疗后6个月患侧关节活动范围为56.5(39.0,128.8)°,显著高于首次治疗前的38.4(22.9,116.3)°(Z = -3.724,P < 0.01),改善显著,提高了17.4(8.0,24.1)°。16例患者末次治疗后6个月瘢痕的VSS评分中血管分布、柔软度、厚度评分及总分均显著低于首次治疗前(Z = -2.989,-3.762,-2.814,-3.739,P < 0.01),其中柔软度改善最明显。6次治疗中,治疗后即刻及治疗后(2.5±0.6)个月首次随访时患侧关节活动范围分别为156.2(148.0,164.2)°和160.2(156.7,166.4)°,均显著高于治疗前的151.4(145.7,155.3)°(Z = -2.201,-2.201,P < 0.05),分别改善显著,提高了9.1(4.4,13.0)°和13.1(8.0,15.7)°。16例患者治疗后治疗区域未观察到水疱、感染或增生性瘢痕形成等不良反应。大多数患者在治疗期间及随访期采用了物理治疗、压迫、硅胶凝胶或硅酮片以及支具。分次二氧化碳激光可软化瘢痕并增加患侧关节活动范围,适用于轻度挛缩性瘢痕的临床治疗。