蛋白磷酸酶 2A 通过滋养层细胞中的 ApoER2 的激活驱动抗磷脂综合征小鼠模型中的子痫前期。
Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.
机构信息
Center for Pulmonary and Vascular Biology, Pediatrics (H.C., A.S., A.N., C.L., K.L.C., P.W.S., C.M.).
Medicine, Hospital for Special Surgery, Weill Cornell Medical College, New York (J.E.S.).
出版信息
Circ Res. 2021 Sep 17;129(7):735-750. doi: 10.1161/CIRCRESAHA.120.318941. Epub 2021 Aug 18.
Abstract
[Figure: see text].
摘要
[图：见正文]。
相似文献
1
Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.蛋白磷酸酶 2A 通过滋养层细胞中的 ApoER2 的激活驱动抗磷脂综合征小鼠模型中的子痫前期。
Circ Res. 2021 Sep 17;129(7):735-750. doi: 10.1161/CIRCRESAHA.120.318941. Epub 2021 Aug 18.
2
Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.抗磷脂抗体通过在血管内皮中形成 apoER2-Dab2-SHC1 复合物激活 PP2A 诱导血栓形成。
Blood. 2018 May 10;131(19):2097-2110. doi: 10.1182/blood-2017-11-814681. Epub 2018 Mar 2.
3
ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.载脂蛋白 E 受体 2 介导抗磷脂抗体诱导的小鼠胎盘功能障碍和妊娠并发症。
Arthritis Rheumatol. 2016 Mar;68(3):730-739. doi: 10.1002/art.39453.
4
Long-chain fatty acid oxidation changes in a β2 glycoprotein I-induced preeclampsia-like mouse model.β2糖蛋白I诱导的子痫前期样小鼠模型中长链脂肪酸氧化的变化
Placenta. 2014 Jun;35(6):392-7. doi: 10.1016/j.placenta.2014.03.013. Epub 2014 Mar 26.
5
Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin.抗磷脂抗体对滋养层血管生成因子分泌的调节作用不能被肝素逆转。
Am J Reprod Immunol. 2011 Oct;66(4):286-96. doi: 10.1111/j.1600-0897.2011.01007.x. Epub 2011 May 4.
6
Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction.胎盘中特异性表达 Hif-1α 导致子痫前期样症状和胎儿生长受限。
Sci Rep. 2019 Feb 26;9(1):2742. doi: 10.1038/s41598-019-39426-5.
7
HIF‑3α affects preeclampsia development by regulating EVT growth via activation of the Flt‑1/JAK/STAT signaling pathway in hypoxia.HIF-3α 通过在缺氧条件下激活 Flt-1/JAK/STAT 信号通路来调节 EVT 生长，从而影响子痫前期的发展。
Mol Med Rep. 2021 Jan;23(1). doi: 10.3892/mmr.2020.11701. Epub 2020 Nov 20.
8
Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia.可溶性内皮糖蛋白在早孕期生理性低氧条件下引起的自噬受损与子痫前期不良胎盘形成有关。
Autophagy. 2013 Mar;9(3):303-16. doi: 10.4161/auto.22927. Epub 2013 Jan 15.
9
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.子痫前期中溶酶体生物发生蛋白质组缺陷和自噬受损的证据。
Autophagy. 2020 Oct;16(10):1771-1785. doi: 10.1080/15548627.2019.1707494. Epub 2019 Dec 26.
10
Hypoxia-induced downregulation of XIAP in trophoblasts mediates apoptosis via interaction with IMUP-2: implications for placental development during pre-eclampsia.缺氧诱导滋养细胞中 XIAP 的下调通过与 IMUP-2 的相互作用介导细胞凋亡：对子痫前期胎盘发育的影响。
J Cell Biochem. 2013 Jan;114(1):89-98. doi: 10.1002/jcb.24304.
引用本文的文献
1
Novel advances on pathophysiological mechanisms, clinical manifestations, and treatment of antiphospholipid syndrome.抗磷脂综合征的病理生理机制、临床表现及治疗方面的新进展。
Front Immunol. 2025 Aug 21;16:1639065. doi: 10.3389/fimmu.2025.1639065. eCollection 2025.
2
B Cell Tolerance and Obstetric Antiphospholipid Syndrome.B细胞耐受性与产科抗磷脂综合征
Clin Rev Allergy Immunol. 2025 Jun 8;68(1):55. doi: 10.1007/s12016-025-09064-z.
3
Maternal Immune Activation: Implications for Congenital Heart Defects.母体免疫激活：对先天性心脏病的影响
Clin Rev Allergy Immunol. 2025 Apr 2;68(1):36. doi: 10.1007/s12016-025-09049-y.
4
Impact of antiphospholipid syndrome on placenta and uterine NK cell function: insights from a mouse model.抗磷脂综合征对胎盘和子宫自然杀伤细胞功能的影响：来自小鼠模型的见解
Sci Rep. 2024 Dec 28;14(1):31163. doi: 10.1038/s41598-024-82451-2.
5
Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental dysfunction by regulating the TRAF6/NF-κB axis.人脐带间充质干细胞来源的外泌体 miR-146a-5p 通过调节 TRAF6/NF-κB 轴缓解抗磷脂抗体诱导的滋养层损伤和胎盘功能障碍。
J Nanobiotechnology. 2023 Nov 13;21(1):419. doi: 10.1186/s12951-023-02179-5.
6
Trophoblast Cell Function in the Antiphospholipid Syndrome.抗磷脂综合征中的滋养层细胞功能
Biomedicines. 2023 Sep 30;11(10):2681. doi: 10.3390/biomedicines11102681.
7
Variable Cre Recombination Efficiency in Placentas of Cyp19-Cre ROSA Transgenic Mice.Cyp19-Cre 转基因小鼠胎盘内可变 Cre 重组效率。
Cells. 2023 Aug 18;12(16):2096. doi: 10.3390/cells12162096.
8
The pathogenesis of obstetric APS: a 2023 update.产科抗磷脂综合征的发病机制：2023 年更新。
Clin Immunol. 2023 Oct;255:109745. doi: 10.1016/j.clim.2023.109745. Epub 2023 Aug 23.
9
Animal Models of Cardiovascular Complications of Pregnancy.妊娠心血管并发症的动物模型。
Circ Res. 2022 Jun 10;130(12):1763-1779. doi: 10.1161/CIRCRESAHA.122.320395. Epub 2022 Jun 9.
10
Differences in Endothelial Activation and Dysfunction Induced by Antiphospholipid Antibodies Among Groups of Patients With Thrombotic, Refractory, and Non-refractory Antiphospholipid Syndrome.血栓形成型、难治型和非难治型抗磷脂综合征患者组中抗磷脂抗体诱导的内皮激活和功能障碍的差异
Front Physiol. 2021 Dec 2;12:764702. doi: 10.3389/fphys.2021.764702. eCollection 2021.
本文引用的文献
1
Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension.补充唾液酸前体 N-乙酰-D-甘露糖胺可打破肥胖与高血压之间的联系。
Circulation. 2019 Dec 10;140(24):2005-2018. doi: 10.1161/CIRCULATIONAHA.119.043490. Epub 2019 Oct 10.
2
Preeclampsia: Pathophysiology, Challenges, and Perspectives.子痫前期：病理生理学、挑战与展望。
Circ Res. 2019 Mar 29;124(7):1094-1112. doi: 10.1161/CIRCRESAHA.118.313276.
3
Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction.胎盘中特异性表达 Hif-1α 导致子痫前期样症状和胎儿生长受限。
Sci Rep. 2019 Feb 26;9(1):2742. doi: 10.1038/s41598-019-39426-5.
4
Reduced Uteroplacental Perfusion Pressure (RUPP) causes altered trophoblast differentiation and pericyte reduction in the mouse placenta labyrinth.低子宫胎盘灌注压（RUPP）导致小鼠胎盘绒毛膜中滋养层分化和周细胞减少。
Sci Rep. 2018 Nov 21;8(1):17162. doi: 10.1038/s41598-018-35606-x.
5
Antiphospholipid antibodies in women with severe preeclampsia and placental insufficiency: a case-control study.重度子痫前期和胎盘功能不全女性中的抗磷脂抗体：一项病例对照研究。
Lupus. 2018 Oct;27(12):1903-1910. doi: 10.1177/0961203318787035. Epub 2018 Jul 20.
6
Hypertensive Disorders of Pregnancy and Cardiovascular Diseases: Current Knowledge and Future Directions.妊娠高血压疾病与心血管疾病：当前认知与未来方向
Curr Treat Options Cardiovasc Med. 2018 Jun 19;20(7):56. doi: 10.1007/s11936-018-0653-8.
7
Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.抗磷脂抗体通过在血管内皮中形成 apoER2-Dab2-SHC1 复合物激活 PP2A 诱导血栓形成。
Blood. 2018 May 10;131(19):2097-2110. doi: 10.1182/blood-2017-11-814681. Epub 2018 Mar 2.
8
Antiphospholipid syndrome.抗磷脂综合征。
Nat Rev Dis Primers. 2018 Jan 11;4:17103. doi: 10.1038/nrdp.2017.103.
9
Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.低唾液酸化 IgG 通过激活血管内皮 IgG 受体 FcγRIIB 促进肥胖诱导的胰岛素抵抗。
J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov 27.
10
PP2A regulates SCF-induced cardiac stem cell migration through interaction with p38 MAPK.蛋白磷酸酶2A（PP2A）通过与p38丝裂原活化蛋白激酶（p38 MAPK）相互作用来调节干细胞因子（SCF）诱导的心脏干细胞迁移。
Life Sci. 2017 Dec 15;191:59-67. doi: 10.1016/j.lfs.2017.10.006. Epub 2017 Oct 3.
Zotero 插件