Diagnosis and prognostic value of C-X-C motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort.

The objective was to identify and validate C-X-C motif chemokine ligand 1() for diagnosis and prognosis in colon adenocarcinoma (COAD). Our current study had enrolled one The Cancer Genome Atlas (TCGA) cohort and two Guangxi cohorts to identify and verify the diagnostic and prognostic values of in COAD. Functional enrichment was performed by gene set enrichment analysis (GSEA). In TCGA cohort, the expression of was significantly up-regulated in tumor tissues and decreased as the tumor stage developed. The receiver operating characteristic (ROC) curve showed that had a high diagnostic value for COAD. The result of Kaplan-Meier survival analysis showed that gene expression (=0.045) was significantly correlated with overall survival (OS) of COAD. Results of Guangxi cohort also verified the diagnostic value of in COAD, and sub-group survival analyses also suggested that patients with high expression were related to a favorable OS (Corrected =0.005). GSEA revealed that high expression phenotype was related to cytokine activity, cell apoptosis, regulation pathway, and regulation of autophagy in COAD. In this study, we found that gene might be a potential diagnostic biomarker for COAD, and might serve as a prognostic biomarker for specific subgroup of COAD.