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病态肥胖:药物治疗还是手术治疗?药物治疗的理由。

Morbid obesity: medical or surgical treatment? The case for medical treatment.

作者信息

Garrow J S

机构信息

Nutrition Research Group, Clinical Research Centre, Harrow, U.K.

出版信息

Int J Obes. 1987;11 Suppl 3:1-4.

PMID:3440685
Abstract

We should ask about any therapy: (1) is it safe? and (2) is it effective? The best therapy is that which has the greatest chance to do good with the least chance to cause harm. Medical treatment is certainly safer than surgery, since (by my definition) surgery always involves a general anaesthetic, and morbidly obese patients are bad anaesthetic risks. Obesity also increases other surgical risks, so all published series of surgically-treated obese patients report some mortality. Surgeons will claim that surgery is much more effective than medical treatment, which has negligible success in morbid obesity. However all surgical bypass or banding procedures cause weight loss by restricting food intake, so if food intake can be equally restricted without surgery the results are just as good. In our experience jaw-wiring (which does not require a general anaesthetic) produces similar weight loss to gastroplasty. However the most difficult problem in morbid obesity is the maintenance of reduced weight many years after treatment. We have too few good long-term follow-up data after either medical or surgical treatment, but about half our patients treated with jaw-wiring and a waist cord maintain their weight loss on 3 years follow-up, zero mortality from the procedure. The results of surgical and medical treatments depend on the skill and care with which they are applied, and the way in which patients are selected. If patients are given treatment B if they are considered unsuitable for treatment A then the results from treatment A will be better.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

我们应该询问任何一种治疗方法

(1)它安全吗?以及(2)它有效吗?最好的治疗方法是那种带来益处的机会最大且造成伤害的机会最小的方法。药物治疗肯定比手术更安全,因为(按照我的定义)手术总是涉及全身麻醉,而病态肥胖患者是麻醉的高风险对象。肥胖还会增加其他手术风险,所以所有已发表的接受手术治疗的肥胖患者系列报告都有一定的死亡率。外科医生会声称手术比药物治疗有效得多,药物治疗在病态肥胖方面几乎没有成功案例。然而,所有的手术旁路或束带手术都是通过限制食物摄入量来导致体重减轻的,所以如果不通过手术能同样限制食物摄入量,结果也是一样好的。根据我们的经验,颌间结扎(不需要全身麻醉)产生的体重减轻与胃成形术相似。然而,病态肥胖中最困难的问题是治疗多年后体重减轻的维持。我们在药物或手术治疗后几乎没有良好的长期随访数据,但接受颌间结扎和腰部束带治疗的患者中,约有一半在3年随访中维持了体重减轻,该手术的死亡率为零。手术和药物治疗的结果取决于应用时的技术和护理,以及患者的选择方式。如果认为患者不适合接受治疗A就给予治疗B,那么治疗A的结果将会更好。(摘要截选至250字)

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