Dept of Pulmonary and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA.
Dept of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Eur Respir Rev. 2021 Aug 17;30(161). doi: 10.1183/16000617.0096-2021. Print 2021 Sep 30.
Plastic bronchitis is a rare, underdiagnosed and potentially fatal condition. It is characterised by the formation and expectoration of branching gelatinous plugs that assume the shape of the airways. These airway plugs differ from the allergic mucin that characterises allergic bronchopulmonary aspergillosis and mucoid impaction of the bronchi. Plastic bronchitis is most often encountered in the paediatric population following corrective cardiac surgery, such as the Fontan procedure. It also occurs in adults. Plastic bronchitis in adults is rare, heterogeneous in its aetiology, and can lead to respiratory distress or even life-threatening airway obstruction. Plastic bronchitis in adulthood should not be overlooked, particularly in patients with chronic inflammatory lung diseases. This review presents current understanding of the presentation, aetiology, pathogenesis, pathology and management of plastic bronchitis in adults.
气道内假膜形成症是一种罕见的、诊断不足且可能致命的疾病。其特征为分支状胶状栓子的形成和咳出,这些栓子的形状与气道相似。这些气道栓子与变应性支气管肺曲霉菌病和支气管黏液嵌塞的变应性黏蛋白不同。气道内假膜形成症最常发生于心脏矫正手术后的儿科人群中,如 Fontan 手术。它也发生于成年人中。成人气道内假膜形成症罕见,病因具有异质性,可导致呼吸窘迫甚至危及生命的气道阻塞。成人气道内假膜形成症不应被忽视,特别是在患有慢性炎症性肺部疾病的患者中。本综述介绍了成人气道内假膜形成症的临床表现、病因、发病机制、病理学和治疗的最新认识。