Abd El-Ghany Shereen M, Tabbakh Aisha T, Nur Khulud I, Abdelrahman Rayan Y, Etarji Sara M, Almuzaini Bayan Y
Department of Pediatrics, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia.
Department of Pediatrics, Hematology and Oncology Unit, Ain Shams University, Cairo, Egypt.
J Blood Med. 2021 Aug 11;12:733-740. doi: 10.2147/JBM.S318824. eCollection 2021.
Sickle cell anemia (SCA) is a chronic hematologic condition that requires frequent hospitalization representing a significant economic burden on the health services. The aim of this study was to explore the causes and underlying factors of hospitalization among children with SCA, as well as the factors affecting their length of hospital stay.
This retrospective study included children and adolescents less than 16 years old who were admitted in a group of private hospitals in Jeddah, Saudi Arabia, during the period from January 2018 to December 2019.
A total of 94 patients were included in this study, 59.6% were males, with a mean age 7.29 ± 3.82 years. The majority of the patients (91.5%) had sickle cell disease. The most common cause of hospital admission was vaso-occlusive crises (VOC) (64.9%) followed by infection (24.5%), acute chest syndrome (ACS) (18.1%), and acute hemolytic crisis (12.8%). We found no significant difference between gender and different causes of admissions (p > 0.05). While in relation to age group, limb pain and back pain were found to be significantly more frequent among children ≥ 7 years old (p = 0.03,0.04), while infections were significantly more frequent among children < 7 years old (p = 0.003). We analyzed the length of hospital stay and different factors, and we found that the mean length of hospital stay was significantly higher among children who were admitted with infections (p = 0.01) and ACS (p < 0.001) and among children who are non-compliant on hydroxyurea (p = 0.04).
The most common cause of hospitalization among children with SCD in Jeddah, Saudi Arabia, was VOC followed by infection, ACS and acute anemia. The length of hospital stay was more prolonged among children with infection and ACS, as well as children who were non-compliant to hydroxyurea.
镰状细胞贫血（SCA）是一种慢性血液疾病，需要频繁住院治疗，给医疗服务带来了巨大的经济负担。本研究的目的是探讨SCA患儿住院的原因和潜在因素，以及影响其住院时间的因素。
本回顾性研究纳入了2018年1月至2019年12月期间在沙特阿拉伯吉达的一组私立医院住院的16岁以下儿童和青少年。
本研究共纳入94例患者，其中59.6%为男性，平均年龄7.29±3.82岁。大多数患者（91.5%）患有镰状细胞病。住院的最常见原因是血管闭塞性危机（VOC）（64.9%），其次是感染（24.5%）、急性胸综合征（ACS）（18.1%）和急性溶血危机（12.8%）。我们发现性别与不同的入院原因之间没有显著差异（p>0.05）。而在年龄组方面，≥7岁的儿童肢体疼痛和背痛的发生率明显更高（p=0.03,0.04），而<7岁的儿童感染的发生率明显更高（p=0.003）。我们分析了住院时间和不同因素，发现因感染（p=0.01）和ACS（p<0.001）入院的儿童以及未遵医嘱服用羟基脲的儿童的平均住院时间明显更长（p=0.04）。
在沙特阿拉伯吉达，SCD患儿住院的最常见原因是VOC，其次是感染、ACS和急性贫血。感染和ACS患儿以及未遵医嘱服用羟基脲的患儿的住院时间更长。
