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评估一种阳离子乳液对泪膜蒸发速率的控制作用。

Assessment of a Cationic Emulsion to Control the Tear Film Evaporation Rate.

作者信息

Abusharha Ali

机构信息

Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi Arabia.

出版信息

Clin Optom (Auckl). 2021 Aug 11;13:243-248. doi: 10.2147/OPTO.S328787. eCollection 2021.

DOI:10.2147/OPTO.S328787
PMID:34408523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8364913/
Abstract

PURPOSE

To investigate the effect of a single application of cationic emulsion in controlling tear film evaporation and improving tear quality and quantity.

MATERIALS A METHODS

Twenty male subjects diagnosed with DE were enrolled in the study with an average age of 45.8 ± 6.37 years. The tear film parameters were observed at several time points post-instillation of the cationic emulsion (10, 20, 30, and 60 min). The tear evaporation rate (TER) was measured with a VapoMeter. Noninvasive tear break-up time and meniscus height were assessed using OCULUS Keratograph.

RESULTS

TER decreased by more than 20% at 20, 30, and 60 minutes time points after instillation of single drop of cationic emulsion. Also, a significant improvement in tear film stability was found at all time points following the instillation of cationic emulsion eye drops. The mean tear break-up time increased from 5.55 ± 2.87 to 6.6 ± 4.2 sec at 60 minutes. The maximum increase in tear break-up time occurred at 30 minutes time point. The TMH was also significantly higher post-instillation of oil emulsion eye drops. There was a significant increase in the TMH post-therapy with oil drop at all time points.

CONCLUSION

The overall study findings of this study illustrate that the single application of a cationic emulsion effectively controls tear film evaporation in patients with mild to moderate DEs. The cationic emulsion efficiently enhanced both the tear film stability and the tear meniscus volume.

摘要

目的

研究单次应用阳离子乳液对控制泪膜蒸发以及改善泪液质量和量的效果。

材料与方法

20名被诊断为干眼的男性受试者参与了该研究，平均年龄为45.8±6.37岁。在滴入阳离子乳液后几个时间点（10、20、30和60分钟）观察泪膜参数。用泪膜蒸发仪测量泪液蒸发率（TER）。使用OCULUS角膜地形图仪评估非侵入性泪膜破裂时间和泪河高度。

结果

滴入单滴阳离子乳液后，在20、30和60分钟时间点TER下降超过20%。此外，滴入阳离子乳液滴眼液后所有时间点泪膜稳定性均有显著改善。60分钟时平均泪膜破裂时间从5.55±2.87秒增加到6.6±4.2秒。泪膜破裂时间的最大增加出现在30分钟时间点。滴入油相乳液滴眼液后泪河高度也显著更高。在所有时间点，滴入油相滴眼液治疗后泪河高度均有显著增加。

结论

本研究的总体研究结果表明，单次应用阳离子乳液可有效控制轻至中度干眼患者的泪膜蒸发。阳离子乳液有效提高了泪膜稳定性和泪河体积。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01df/8364913/fa060a03eb1e/OPTO-13-243-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01df/8364913/a0e0ca6ef5f7/OPTO-13-243-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01df/8364913/7be2a99e5a18/OPTO-13-243-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01df/8364913/fa060a03eb1e/OPTO-13-243-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01df/8364913/a0e0ca6ef5f7/OPTO-13-243-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01df/8364913/7be2a99e5a18/OPTO-13-243-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01df/8364913/fa060a03eb1e/OPTO-13-243-g0003.jpg

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Formulation Considerations for the Management of Dry Eye Disease.干眼症管理的制剂考量
Pharmaceutics. 2021 Feb 3;13(2):207. doi: 10.3390/pharmaceutics13020207.
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Prophylactic action of lipid and non-lipid tear supplements in adverse environmental conditions: A randomised crossover trial.
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Ocul Surf. 2020 Oct;18(4):920-925. doi: 10.1016/j.jtos.2020.08.004. Epub 2020 Aug 15.
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A Comparison of Efficacy and Safety of Two Lipid-Based Lubricant Eye Drops for the Management of Evaporative Dry Eye Disease.两种脂质基润滑眼药水治疗蒸发型干眼疾病的疗效与安全性比较
Clin Ophthalmol. 2020 Jun 18;14:1665-1673. doi: 10.2147/OPTH.S256351. eCollection 2020.
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Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease.阳离子乳化人工泪液模拟功能性健康泪膜，用于恢复干眼疾病中的眼表面稳态。
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