Makri Olga E, Tsekouras Iasonas, Mastronikolis Stylianos, Georgakopoulos Constantinos D
Department of Ophthalmology, Medical School, University of Patras, Patras, Greece.
Med Hypothesis Discov Innov Ophthalmol. 2021 May 31;10(1):5-10. doi: 10.51329/mehdiophthal1415. eCollection 2021 Spring.
This study investigated the effect of instilling a single drop of non-preserved cationic oil-in- water ophthalmic emulsion (Cationorm®) on the lower (LTM) and upper tear meniscus (UTM) parameters of normal eyes.
In this prospective, single-center, non-randomized, controlled pilot study, optical coherence tomography was used to estimate the UTM and LTM height, depth, and cross-sectional area in participants without a history of dry eye disease. In the right eye (study eye), we instilled one drop of Cationorm® in the lower conjunctival sac. Scans of the tear menisci were acquired at baseline, before the instillation, and at 5, 15, and 30 min thereafter. Control scans of the left eye (control eye) were obtained at the same timepoints. The tear meniscus parameters of the study eye were compared with the control eye at each timepoint.
Twenty subjects (11 male and 9 female; mean [standard deviation] of age: 37.8 [10.9] years) were included in the study. Compared to the control eye, instillation of a single drop of Cationorm® resulted in significantly higher LTM parameter values and a higher UTM cross-sectional area up to 30 min after instillation (all < 0.05). The UTM height and depth were significantly greater in the study eye than in the control eye up to 5 min ( < 0.001 and 0.007, respectively) and 15-min ( = 0.045, and 0.002, respectively) after Cationorm® instillation. In the study eye, Cationorm® resulted in a significant increase in LTM parameter values up to 30 min post-instillation (all < 0.001). The UTM height was significantly greater up to 15 min post-instillation than at baseline. The UTM depth and area increased significantly from baseline to 5 min after instillation ( = 0.043, and 0.002, respectively).
Cationorm® seems to have a prolonged residence time on the ocular surface of healthy subjects as indicated by LTM parameters and to a lesser extent by UTM parameters.
本研究调查了向正常眼的下泪液弯月面（LTM）和上泪液弯月面（UTM）滴入一滴未保存的阳离子水包油型眼科乳剂（Cationorm®）的效果。
在这项前瞻性、单中心、非随机对照试验研究中，使用光学相干断层扫描来评估无干眼病史参与者的UTM和LTM的高度、深度及横截面积。在右眼（研究眼）的下结膜囊中滴入一滴Cationorm®。在基线、滴入前以及滴入后5分钟、15分钟和30分钟获取泪液弯月面的扫描图像。在相同时间点获取左眼（对照眼）的对照扫描图像。在每个时间点将研究眼的泪液弯月面参数与对照眼进行比较。
20名受试者（11名男性和9名女性；年龄均值[标准差]：37.8[10.9]岁）纳入研究。与对照眼相比，滴入一滴Cationorm®后，LTM参数值显著更高，且在滴入后30分钟内UTM横截面积更大（均P<0.05）。在滴入Cationorm®后5分钟内（分别为P<0.001和0.007）以及15分钟内（分别为P=0.045和0.002），研究眼中UTM的高度和深度显著大于对照眼。在研究眼中，Cationorm®导致滴入后30分钟内LTM参数值显著增加（均P<0.001）。滴入后15分钟内UTM高度显著高于基线。UTM深度和面积从基线到滴入后5分钟显著增加（分别为P=0.043和0.002）。
如LTM参数所示，Cationorm®似乎在健康受试者眼表具有较长的停留时间，UTM参数在较小程度上也有体现。
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