McGuffin P, Katz R, Bebbington P
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, U.K.
J Psychiatr Res. 1987;21(4):365-75. doi: 10.1016/0022-3956(87)90083-5.
The relationship between proband characteristics and familial aggregation of depression was assessed in an interview study of 83 families ascertained via probands who had a recent onset of depression. Contrary to expectations and to previous reports in the literature there were no differences between the frequencies of depression in the first degree relatives of probands who had or had not experienced adversity prior to the onset of their illness. Depression was actually slightly more common among the first degree relatives of probands who had experienced a threatening life event compared with the relatives of those who had not. Early onset of depression (before 32 yr) and a neurotic pattern of symptoms in probands were associated with significantly higher rates of current illness in relatives. However, both these differences disappeared when lifetime prevalence or morbid risk to age 65 were considered. Indeed the morbid risk of severe depression in the relatives of endogenously depressed probands was nearly twice that in the relatives of neurotic probands.
在一项针对83个家庭的访谈研究中，通过近期首次发作抑郁症的先证者确定了这些家庭，评估了先证者特征与抑郁症家族聚集性之间的关系。与预期及文献中先前的报道相反，在发病前经历或未经历过逆境的先证者的一级亲属中，抑郁症的发病率没有差异。实际上，与未经历过威胁生命事件的先证者的亲属相比，经历过此类事件的先证者的一级亲属中抑郁症更为常见。先证者抑郁症的早发（32岁之前）和神经质症状模式与亲属当前疾病的显著更高发病率相关。然而，当考虑终生患病率或65岁时的患病风险时，这两个差异都消失了。事实上，内源性抑郁症先证者亲属中重度抑郁症的患病风险几乎是神经质先证者亲属的两倍。
