Sitaram N, Dube S, Keshavan M, Davies A, Reynal P
Lafayette Clinic, Detroit, Michigan.
J Psychiatr Res. 1987;21(4):487-97. doi: 10.1016/0022-3956(87)90097-5.
Based on the Rieder and Gershon (1978) biological genetic study paradigm we compared the prevalence of a putative vulnerability factor (rapid cholinergic REM sleep induction) between 35 affectively ill and 31 well first-degree relatives of 34 probands chosen on the basis of presence of primary affective illness and positive marker status. A significantly higher percentage of ill relatives (63%, 22 out of 35 subjects) had a supersensitive REM-induction response as compared to well relatives (22%, 7 out of 31 subjects). Since the current study does not rule out the effects of prior depressive episodes or treatment on cholinergic sensitivity, caution must be exercised in the interpretation of our findings.
基于里德和格申（1978年）的生物遗传学研究范式，我们比较了35名情感障碍患者和31名健康一级亲属中假定的易感性因素（快速胆碱能快速眼动睡眠诱导）的患病率，这些亲属是从34名先证者的亲属中挑选出来的，先证者基于原发性情感障碍的存在和阳性标志物状态进行选择。与健康亲属（22%，31名受试者中有7名）相比，患病亲属中具有超敏快速眼动诱导反应的比例显著更高（63%，35名受试者中有22名）。由于当前研究并未排除既往抑郁发作或治疗对胆碱能敏感性的影响，因此在解释我们的研究结果时必须谨慎。
