Birong Dong, PhD, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China, Email:
J Nutr Health Aging. 2021;25(7):909-913. doi: 10.1007/s12603-021-1645-z.
Sarcopenia is a condition associated with progressive loss of skeletal muscle mass and function resulting in substantial negative health outcomes and disability in older adults. It is thus important that sarcopenia-related risk factors be explored. The present study was based upon the Asian Working Group on Sarcopenia 2019 (AWGS2019) criteria to assess whether vitamin D levels are a risk factor associated with sarcopenia in various ethnic groups in western China.
Cross-sectional study.
Communities in Yunnan, Guizhou, Sichuan, and Xinjiang provinces.
We included 4236 individuals that were 50 years of age or older from the West China Health and Aging Trend (WCHAT) study.
An InBody 770 instrument was used for bioimpedance-based analyses of muscle mass, while a digital grip strength dynamometer was used for handgrip strength-based measurements of muscle strength. Physical performance was assessed based upon gait speed over 4 m. Other secondary variables were additionally analyzed as potentially relevant risk factors.
Sarcopenia affected an estimated 22.45% of studied individuals who were 50 years of age or older, with respective prevalence rates in the < 60, 60-64, 65-79, and ≥80 age groups of 11.78%,19.44%, 32.65%, and 67.97%. Rates in males and females were 26.66% and 20.05%, respectively. In males, a significant difference in vitamin D levels was detected when comparing individuals with and without sarcopenia, although no such relationship was detected in females. Following adjustment for confounding variables, binary logistic regression analyses revealed that inadequate vitamin D was able to independently predict sarcopenia risk only in males (OR=1.875,95%CI: 1.109-3.169, P=0.019).
Among middle-aged and older adults of multiple ethnicities in western China, we found that inadequate vitamin D was an independent predictor of sarcopenia risk specifically in males.
肌少症是一种与骨骼肌量和功能进行性丧失相关的病症，会导致老年人健康状况恶化和残疾。因此，探索与肌少症相关的危险因素非常重要。本研究基于亚洲肌少症工作组 2019 年（AWGS2019）标准，评估维生素 D 水平是否是中国西部不同种族人群肌少症的相关危险因素。
横断面研究。
云南、贵州、四川和新疆三省的社区。
我们纳入了来自中国西部健康与老龄化趋势研究（WCHAT）的 4236 名 50 岁及以上的个体。
使用 InBody 770 仪器进行基于生物阻抗的肌肉量分析，使用数字握力测力计进行基于手握力的肌肉力量测量。根据 4 米的步态速度评估身体机能。还分析了其他次要变量作为潜在的相关危险因素。
估计有 22.45%的 50 岁及以上研究对象患有肌少症，<60 岁、60-64 岁、65-79 岁和≥80 岁年龄组的患病率分别为 11.78%、19.44%、32.65%和 67.97%。男性和女性的患病率分别为 26.66%和 20.05%。在男性中，患有和不患有肌少症的个体之间维生素 D 水平存在显著差异，而在女性中则没有这种关系。在校正混杂因素后，二元逻辑回归分析显示，维生素 D 不足仅能独立预测男性肌少症风险（OR=1.875，95%CI：1.109-3.169，P=0.019）。
在中国西部的多个民族的中年和老年人中，我们发现维生素 D 不足是男性肌少症风险的一个独立预测因素。
