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Clin Biochem. 2021 Apr;90:23-27. doi: 10.1016/j.clinbiochem.2021.01.004. Epub 2021 Jan 17.
3
Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases.无症状、轻症和重症 SARS-CoV-2 感染者的固有和适应性免疫反应不同。
Front Immunol. 2020 Dec 16;11:610300. doi: 10.3389/fimmu.2020.610300. eCollection 2020.
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J Cell Mol Med. 2020 Dec;24(24):14270-14279. doi: 10.1111/jcmm.16044. Epub 2020 Nov 3.
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Surveillance of early stage COVID-19 clusters using search query logs and mobile device-based location information.利用搜索查询日志和基于移动设备的位置信息监测 COVID-19 早期集群。
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9
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Development of Genetic Diagnostic Methods for Detection for Novel Coronavirus 2019(nCoV-2019) in Japan.日本新型冠状病毒 2019(nCoV-2019)基因诊断方法的建立。
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九例 SARS-CoV-2-PCR 阳性样本显示对 SARS-CoV-2 的抗体无增加。

Nine Cases of SARS-CoV-2-PCR-positive Samples Showed No Increase of Antibodies Against SARS-CoV-2.

机构信息

Advanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.

School of Nursing and Social Services, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.

出版信息

In Vivo. 2021 Sep-Oct;35(5):2947-2949. doi: 10.21873/invivo.12587.

DOI:10.21873/invivo.12587
PMID:34410992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8408738/
Abstract

BACKGROUND/AIM: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been affecting Hokkaido, Japan since late February 2020 until present. The aim of this study was to report the relationship between anti-SARS-CoV-2 antibody-positive and SARS-CoV-2 PCR-positive cases by analyzing anti-SARS-CoV-2 antibodies (IgG and total-Ig).

PATIENTS AND METHODS

Serum samples were collected from care workers and nurses in two nursing homes and two hospitals which underwent virus outbreak. All people were confirmed to be SARS-CoV-2-positive by RT-qPCR and their sera was analyzed for anti-SARS-CoV-2 antibodies (IgG and total-Ig).

RESULTS

Although 34 out of 43 samples (79.1%) showed enough amount of anti-SARS-CoV-2 antibodies, 9 RT-qPCR -positive samples (20.9%) showed absence of anti-SARS-CoV-2 antibodies in their sera.

CONCLUSION

The results that 20.9% of RT-qPCR-positive samples with SARS-CoV-2 showed absence of anti-SARS-CoV-2 antibodies provides a possibility that the innate immune reaction could eliminate the virus without activating adaptive immune reaction.

摘要

背景/目的：自 2020 年 2 月底以来，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）一直在日本北海道流行。本研究旨在通过分析抗 SARS-CoV-2 抗体（IgG 和总 Ig），报告抗 SARS-CoV-2 抗体阳性和 SARS-CoV-2 PCR 阳性病例之间的关系。

患者和方法

从两家养老院和两家发生病毒爆发的医院的护理人员和护士中采集血清样本。所有患者均通过 RT-qPCR 确认为 SARS-CoV-2 阳性，并对其血清进行抗 SARS-CoV-2 抗体（IgG 和总 Ig）分析。

结果

尽管 43 份样本中有 34 份（79.1%）显示出足够量的抗 SARS-CoV-2 抗体，但 9 份 RT-qPCR 阳性样本（20.9%）的血清中未检测到抗 SARS-CoV-2 抗体。

结论

20.9%的 SARS-CoV-2 RT-qPCR 阳性样本未检测到抗 SARS-CoV-2 抗体的结果提示，固有免疫反应可能在激活适应性免疫反应之前就已清除了病毒。