母亲体重指数与复发性妊娠丢失的均值差异：观察性研究的系统评价和荟萃分析。
Mean differences in maternal body mass index and recurrent pregnancy loss: a systematic review and meta-analysis of observational studies.
机构信息
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
出版信息
Fertil Steril. 2021 Nov;116(5):1341-1348. doi: 10.1016/j.fertnstert.2021.06.019. Epub 2021 Aug 17.
Abstract
OBJECTIVE
To investigate the association of maternal body mass index (BMI) and recurrent pregnancy loss (RPL).
DESIGN
Systematic review and meta-analysis.
SETTING
Not applicable.
PATIENT(S): A total of 3,833 women with RPL and 4,083 women as controls.
INTERVENTION(S): Studies were identified through a search of PubMed, Embase, Scopus, and Cochrane.
MAIN OUTCOME MEASURE(S): The primary outcome of interest was RPL using the mean differences in maternal BMI as the predictor variable. The results of the meta-analysis were reported as the mean difference with a 95% confidence interval.
RESULT(S): In total, 892 studies were reviewed. Pooled data from 25 studies suggested that the maternal BMI of women with a history of recurrent pregnancy loss was significantly higher than the BMI of controls, mean difference 0.7 kg/m [95% confidence interval 0.2-1.3].
CONCLUSION(S): These findings supported an association between maternal BMI and RPL. Large prospective studies are needed to evaluate the influence of maternal BMI on pregnancy outcomes in women with RPL.
摘要
目的
探讨母体体重指数（BMI）与复发性妊娠丢失（RPL）的关系。
设计
系统评价和荟萃分析。
环境
不适用。
患者
共有 3833 名 RPL 妇女和 4083 名作为对照的妇女。
干预措施
通过检索 PubMed、Embase、Scopus 和 Cochrane 来确定研究。
主要观察指标
以母体 BMI 作为预测变量的 RPL 是主要的观察指标。荟萃分析的结果以均值差和 95%置信区间表示。
结果
共综述了 892 项研究。25 项研究的汇总数据表明，有反复妊娠丢失史的女性的母体 BMI 明显高于对照组，平均差异为 0.7kg/m[95%置信区间 0.2-1.3]。
结论
这些发现支持母体 BMI 与 RPL 之间的关联。需要进行大型前瞻性研究，以评估 RPL 妇女的母体 BMI 对妊娠结局的影响。
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