Pekcan Meryem Kuru, Sarıkaya Esma, Tokmak Aytekin, Alışık Murat, Alkan Afra, Özakşit Gülnur, Erel Özcan
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
Kaohsiung J Med Sci. 2017 Jan;33(1):30-35. doi: 10.1016/j.kjms.2016.10.010. Epub 2016 Dec 20.
A disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs (ADAMTS) protein superfamily includes 19 secreted metalloproteases. Proteolytic substrates of ADAMTS enzymes have been linked to reproductive function. The aim of this study was to investigate serum ADAMTS-3, -13, -16, and -19 levels in women with habitual abortions compared with those in healthy controls. A total of 86 women were enrolled in this prospective case-control study. ADAMTS-3, -13, -16, and -19 values were recorded and analyzed in association with demographic and clinical parameters. There were no statistically significant differences between the two groups in terms of demographics. No statistically significant differences were observed between the groups with regard to ADAMTS-13 and -19 levels (p>0.05). However, ADAMTS-3 and -16 were significantly higher in the study group than in the control group (p=0.004 and p=0.005, respectively). To estimate habitual abortions using an area under receiver operating characteristic curve analysis, the cutoff values for ADAMTS-3 and -16 were found to be 87.28 ng/mL (sensitivity, 64.44%; specificity 68.29%) and 15.75 ng/mL (sensitivity, 66.67%; specificity 68.29%), respectively. In conclusion, the pregnancy-loss rate seems to be affected by both ADAMTS-3 and -16.
具有血小板反应蛋白-1型基序的解整合素样金属蛋白酶（ADAMTS）蛋白超家族包括19种分泌型金属蛋白酶。ADAMTS酶的蛋白水解底物与生殖功能有关。本研究的目的是调查习惯性流产女性血清中ADAMTS-3、-13、-16和-19的水平，并与健康对照组进行比较。共有86名女性参与了这项前瞻性病例对照研究。记录并分析了ADAMTS-3、-13、-16和-19的值，并将其与人口统计学和临床参数相关联。两组在人口统计学方面无统计学显著差异。在ADAMTS-13和-19水平上，两组之间未观察到统计学显著差异（p>0.05）。然而，研究组中的ADAMTS-3和-16显著高于对照组（分别为p=0.004和p=0.005）。通过受试者工作特征曲线分析下的面积来估计习惯性流产，发现ADAMTS-3和-16的截断值分别为87.28 ng/mL（敏感性为64.44%；特异性为68.29%）和15.75 ng/mL（敏感性为66.67%；特异性为68.29%）。总之，流产率似乎受ADAMTS-3和-16两者的影响。
