Department of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Med+ Biomaterial Institute of West China Hospital/West China School of Medicine of Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2021 Aug 3;12:722941. doi: 10.3389/fendo.2021.722941. eCollection 2021.
This study aimed to assess the relationship between dietary inflammatory index (DII) and sex hormones in male children and adolescents aged 6-19 years.
We obtained data from the 2013-2016 National Health and Nutrition Examination Survey (NHANES). Male participants aged 6-19 years old with the complete data of DII and sex hormones were included. Weighted multiple regression analysis and subgroup analysis were preformed to estimate the independent relationship between DII and sex hormones.
A total of 1717 male participants with the average age of 13.02 ± 3.82 years were enrolled, of whom 41.3% (n=713) were children and 58.47% (n=1004) were adolescents. In children, mean DII was 0.18 ± 1.67, with scores ranging from -4.53 to 4.08. As for adolescents, the mean DII was 0.36 ± 1.98, mean total testosterone (TT) was 376.94 ± 206.69 ng/dl overall. A negative association between DII with TT and estradiol (E2) was observed (TT: β=-11.97, P=0.0006; E2: β=-0.45, P=0.0108) in male adolescent. Subgroup analysis and interaction test results indicated that this association was similar in male adolescents with different body mass index. No statistically significant association was observed in children.
Pro-inflammatory diet was associated with lower TT and E2 level in male adolescent, while no association with statistical significance between them was observed in male children. However, more studies are still needed to validate the causal relationship between DII and sex hormones.
本研究旨在评估男性儿童和青少年的饮食炎症指数（DII）与性激素之间的关系。
我们从 2013-2016 年全国健康与营养调查（NHANES）中获取数据。纳入年龄在 6-19 岁、DII 和性激素数据完整的男性参与者。采用加权多重回归分析和亚组分析来评估 DII 与性激素之间的独立关系。
共纳入 1717 名平均年龄为 13.02±3.82 岁的男性参与者，其中 41.3%（n=713）为儿童，58.47%（n=1004）为青少年。在儿童中，DII 的平均值为 0.18±1.67，分值范围为-4.53 至 4.08。对于青少年，DII 的平均值为 0.36±1.98，总睾酮（TT）的平均值为 376.94±206.69ng/dl。DII 与 TT 和雌二醇（E2）呈负相关（TT：β=-11.97，P=0.0006；E2：β=-0.45，P=0.0108），这在男性青少年中是一致的。亚组分析和交互检验结果表明，在不同体质指数的男性青少年中，这种相关性是相似的。在儿童中未观察到有统计学意义的相关性。
促炎饮食与男性青少年 TT 和 E2 水平较低有关，而在男性儿童中两者之间没有统计学意义上的关联。然而，仍需要更多的研究来验证 DII 与性激素之间的因果关系。
