Department of Internal Medicine II, Centre for Complementary Medicine, Freiburg University Hospital, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Unit of Oncology and Radiotherapy, Pereira Rossell Women's Hospital, Bvard. Artigas 1590, Montevideo 11600, Uruguay.
Nutrients. 2023 Jul 7;15(13):3075. doi: 10.3390/nu15133075.
The dietary acid load (DAL) is a novel marker of overall diet quality, which has been associated with overweight, type 2 diabetes and altered glucocorticoid secretion. A potential association with sex hormones is thus not inconceivable. We investigated whether DAL was associated with serum total testosterone concentrations of men in the National Health and Nutrition Examination Survey. The DAL scores, including the potential renal acid load (PRAL) and net endogenous acid production (NEAP), were estimated and compared between participants with low and normal testosterone levels. The investigated sample encompassed = 377 males with a mean age of 49.50 years. Approximately 73% of the sample were of Non-Hispanic White origin. None of the examined DAL scores showed significant associations with serum testosterone levels. We observed no significant differences in the crude DAL scores between individuals with low testosterone levels and individuals with normal testosterone levels. Multivariate regression models adjusting for covariates confirmed the lack of associations between the PRAL and serum testosterone. Our results are of particular importance for those individuals who wish to lower their DAL in light of the presumable health effects of a more alkaline diet. Our data suggest that diet modifications toward a lower intake of animal protein and refined grains (which consecutively translates into a lower DAL) may not negatively affect men's testosterone levels.
饮食酸负荷（DAL）是一种新的整体饮食质量标志物，它与超重、2 型糖尿病和糖皮质激素分泌改变有关。因此，它与性激素之间存在潜在的关联并非不可思议。我们研究了 DAL 是否与美国国家健康和营养调查中男性的血清总睾酮浓度有关。我们估计并比较了 DAL 评分（包括潜在肾酸负荷（PRAL）和净内源性酸产生（NEAP））在低睾酮和正常睾酮水平的参与者之间的差异。研究样本包括 377 名平均年龄为 49.50 岁的男性。样本中约 73%是非西班牙裔白人。没有任何 DAL 评分与血清睾酮水平呈显著相关性。我们观察到低睾酮水平个体与正常睾酮水平个体之间的 DAL 评分无显著差异。调整协变量的多元回归模型证实，PRAL 与血清睾酮之间不存在关联。我们的结果对于那些希望降低 DAL 的人特别重要，因为假定碱性饮食对健康有影响。我们的数据表明，饮食向低动物蛋白和精制谷物（这会导致 DAL 降低）的调整可能不会对男性的睾酮水平产生负面影响。
