College of Life Science and Technology, Jilin Agricultural University, Changchun, Jilin, China.
College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang, 163319, China.
Environ Toxicol Pharmacol. 2021 Oct;87:103725. doi: 10.1016/j.etap.2021.103725. Epub 2021 Aug 18.
The objective of this study was to evaluate the toxic effects of Cr on bioaccumulation, digestion, immunity, oxidative stress, apoptosis and inflammation-related genes in Channa asiatica. The fish was exposed to waterborne Cr concentrations (0, 0.5, 1.0 and 2.0 mg/L) for 28 and 56 days. Our results demonstrated that the accumulation of Cr in tissues increased in a concentration-dependent manner, and the content in tissue was liver > gill > gut > muscle. Meanwhile, Cr exposure led to a remarkable suppression of digestion, immunity and antioxidant capacity in C. asiatica. Inversely, MDA and PC content were positively correlated with Cr exposure concentration. Furthermore, the expression of genes went up with the increase of waterborne Cr concentration. Among them, HSP90, NF-κB and TNF-α have a sharp increase. These results elucidate that waterborne Cr exposure may induce bioaccumulation, inhibit digestion and immunity, promote oxidative stress and up-regulate the expression of apoptosis and inflammation-related genes in C. asiatica.
本研究旨在评估 Cr 对中华鳖生物累积、消化、免疫、氧化应激、凋亡和炎症相关基因的毒性作用。鱼在水中暴露于不同浓度的 Cr（0、0.5、1.0 和 2.0mg/L）28 天和 56 天。结果表明，Cr 在组织中的积累呈浓度依赖性增加，组织中含量为肝＞鳃＞肠＞肌肉。同时，Cr 暴露导致中华鳖消化、免疫和抗氧化能力显著抑制。相反，MDA 和 PC 含量与 Cr 暴露浓度呈正相关。此外，基因的表达随水中 Cr 浓度的增加而上调。其中，HSP90、NF-κB 和 TNF-α 有明显增加。这些结果表明，水相 Cr 暴露可能导致生物累积，抑制消化和免疫，促进氧化应激，并上调中华鳖凋亡和炎症相关基因的表达。
