Department of Otorhinolaryngology/Head and Neck Surgery, Gazi University Hospital, Ankara, Turkey.
Gazi Üniversitesi Tıp Fakültesi, Beşevler, Ankara, Turkey.
Head Neck Pathol. 2022 Jun;16(2):596-601. doi: 10.1007/s12105-021-01375-9. Epub 2021 Aug 21.
SMARCB1 (INI1) deficient carcinoma (SDC) is a newly-described, aggressive, high-grade malignancy of the adult population. Rarely, these tumors demonstrate yolk sac differentiation. Treatment protocols are not defined due to the rarity of this entity. A 55 year-old-male presented with a tumor originating in the maxillary sinus. He was treated with neoadjuvant therapy followed by radical surgery and adjuvant treatment. We review the literature and discuss the course of disease and treatments of sinonasal SDC with yolk sac tumor differentiation. To our knowledge, this is the sixth reported case of sinonasal SDC with yolk sac tumor differentiation. This is the first publication describing the clinical course and efficacy of therapeutic interventions.
SMARCB1（INI1）缺陷型癌（SDC）是一种新描述的、侵袭性的、成人人群中的高级别恶性肿瘤。这些肿瘤很少表现出卵黄囊分化。由于该实体的罕见性，治疗方案尚未确定。一名 55 岁男性出现起源于上颌窦的肿瘤。他接受了新辅助治疗，随后进行了根治性手术和辅助治疗。我们回顾了文献，讨论了具有卵黄囊肿瘤分化的鼻旁窦 SDC 的疾病过程和治疗方法。据我们所知，这是第六例报告的具有卵黄囊肿瘤分化的鼻旁窦 SDC。这是第一篇描述临床过程和治疗干预效果的出版物。
