新版世界卫生组织鼻窦癌分类中分子定义实体的临床病理特征及预后结果
Clinicopathological features and prognostic outcomes of molecularly defined entities in the new edition of the WHO classification of sinonasal carcinoma.
作者信息
Vuong Huy Gia, Le Thoa, Le Trang T B, Le Hieu Trong, El-Rassi Edward T, McKinney Kibwei A, Dunn Ian F
机构信息
Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, United States.
Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
出版信息
Front Oncol. 2023 Mar 1;13:1117865. doi: 10.3389/fonc.2023.1117865. eCollection 2023.
INTRODUCTION
We investigated the clinicopathological features and prognoses of the new molecularly defined entities in latest edition of the World Health Organization (WHO) classification of sinonasal carcinoma (SNC).
METHODS
Integrated data were combined into an individual patient data (IPD) meta-analysis.
RESULTS
We included 61 studies with 278 SNCs including 25 mutant, 41 NUT carcinoma, 187 SWI/SNF loss, and 25 triple negative SNCs (without IDH2 mutation, rearrangement, and SWI/SNF inactivation) for analyses. Compared to other molecular groups, NUT carcinoma was associated with a younger age at presentation and an inferior disease-specific survival. Among SNCs with SWI/SNF inactivation, deficient tumors presented later in life and were associated with a higher rate of radiotherapy administration. deficiency was mostly found in teratocarcinosarcoma while deficient tumors were associated with undifferentiated carcinoma and non-keratinizing squamous cell carcinoma.
CONCLUSION
Our study facilitates our current understanding of this developing molecular-defined spectrum of tumors and their prognoses.
引言
我们研究了世界卫生组织（WHO）最新版鼻窦癌（SNC）分类中新的分子定义实体的临床病理特征和预后。
方法
将综合数据合并为个体患者数据（IPD）荟萃分析。
结果
我们纳入了61项研究，共278例SNC，其中包括25例突变型、41例NUT癌、187例SWI/SNF缺失型和25例三阴性SNC（无IDH2突变、重排和SWI/SNF失活）进行分析。与其他分子组相比，NUT癌与发病年龄较轻和疾病特异性生存率较低相关。在SWI/SNF失活的SNC中，缺陷型肿瘤发病较晚，且放疗率较高。缺陷主要见于畸胎癌肉瘤，而缺陷型肿瘤与未分化癌和非角化鳞状细胞癌相关。
结论
我们的研究有助于我们目前对这种不断发展的分子定义肿瘤谱及其预后的理解。
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