小鼠B族III型链球菌感染的黏蛋白模型。
Mucin model for group B type III streptococcal infection in mice.
作者信息
Fleming D O
出版信息
Infect Immun. 1980 Feb;27(2):449-54. doi: 10.1128/iai.27.2.449-454.1980.
Abstract
An experimental murine infection was established by the intraperitoneal injection of a log-phase culture of a laboratory reference strain of Streptococcus agalactiae, Lancefield group B, type III (strain SS620), suspended in sterile hog gastric mucin. The enhancement of streptococcal virulence was measured by a significantly increased mortality in outbred ICR Swiss mice. An inbred C57BL6 strain of mice was resistant to the mucin-bacterial combination. Mucin, treated with Desferal to chelate the iron, did not lose the capacity to enhance the virulence of group B, type III streptococci in ICR Swiss mice. Iron-dextran was not a suitable substitute for mucin and failed to enhance the virulence of group B, type III streptococci. The results of these studies indicate that iron is not the resistance-lowering factor in this group B, type III streptococci-mucin model.
摘要
通过腹腔注射悬浮于无菌猪胃粘蛋白中的B群链球菌III型实验室参考菌株（菌株SS620）的对数期培养物，建立了实验性小鼠感染模型。通过远交系ICR瑞士小鼠死亡率显著增加来衡量链球菌毒力的增强。近交系C57BL6小鼠品系对粘蛋白 - 细菌组合具有抗性。用去铁胺处理以螯合铁的粘蛋白，并未丧失增强ICR瑞士小鼠中B群III型链球菌毒力的能力。右旋糖酐铁不是粘蛋白的合适替代品，不能增强B群III型链球菌的毒力。这些研究结果表明，在该B群III型链球菌 - 粘蛋白模型中，铁不是降低抗性的因素。
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