Kretschmer R, Vogel L C, Kelly P, Padnos D, Goldman M, Adueh W M, Gotoff S P
Infection. 1980;8(2):54-7. doi: 10.1007/BF01639146.
We examined the role of serum, complement and the reticuloendothelial system in mouse resistance to type III group B streptococci (GBS). Normal serum obtained from 21 day-old mice failed to protect chick embryos against a lethal intravenous (IV) inoculation of GBS-III-SS620/50. Mice that were decomplemented using cobra venom factor remained resistant to intraperitoneal (IP) inoculation of 10(6) colony-forming units (CFU) of GBS-III-22620/50, GBS III-Bell and GBS-III-Minnesota. In contrast, mice prepared with IP oleic acid were killed with 10(4) CFU of GBS-III-SS620/50 IP. However, when mice were injected IV with oleic acid, they remained resistant to IP inoculation of GBS-III-SS620/50. These results suggest that peritoneal macrophages play a role in murine defense against IP infection with GBS-III-SS620/50.
我们研究了血清、补体和网状内皮系统在小鼠对B族链球菌III型（GBS）抵抗力中的作用。从21日龄小鼠获得的正常血清未能保护鸡胚免受GBS-III-SS620/50致死性静脉注射。用眼镜蛇毒因子进行补体灭活的小鼠对腹腔注射10⁶ 菌落形成单位（CFU）的GBS-III-22620/50、GBS III-Bell和GBS-III-明尼苏达仍具抵抗力。相比之下，腹腔注射油酸制备的小鼠经腹腔注射10⁴ CFU的GBS-III-SS620/50会死亡。然而，当小鼠静脉注射油酸时，它们对腹腔注射GBS-III-SS620/50仍具抵抗力。这些结果表明，腹膜巨噬细胞在小鼠抵御GBS-III-SS620/50腹腔感染中发挥作用。
