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经端口入路再次二尖瓣手术

Reoperative Mitral Valve Surgery Through Port Access.

作者信息

Ko Kinsing, de Kroon Thom L, Kelder Johannes C, Saouti Nabil, van Putte Bart P

机构信息

Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands; Cardiothoracic Surgery, Radboud UMC, Nijmegen, The Netherlands.

Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands.

出版信息

Semin Thorac Cardiovasc Surg. 2022 Winter;34(4):1208-1217. doi: 10.1053/j.semtcvs.2021.08.014. Epub 2021 Aug 21.

Abstract

Minimally invasive mitral valve surgery (MIMVS) has become the standard approach for mitral valve pathology in many centres. The anterolateral mini thoracotomy access is beneficial in reoperative surgery by avoiding repeat sternotomy associated risks. The aim of this study is to analyse the safety of this technique. All patients undergoing reoperative MIMVS between 2008 and 2019 were studied retrospectively. Primary endpoint was 30-day major complications and mortality; secondary outcome was long term survival, reoperation rate and rate of more than moderate recurrent regurgitation. 146 Patients underwent reoperative MIMVS with a mean age of 68 ± 8 years. The composite outcome of 30-day major complication and mortality was 29.5%. 30-Day mortality was 6.2% and stroke rate 3.4%. Survival for the whole cohort was 89.7 ± 2.5% at 1-year, 71.6 ± 4.3% at 5 year and 50.9 ± 5.9% at 8-year follow up. Cox regression analysis revealed reduced left ventricular function (HR 2.8; 95%CI 1.5 - 5.0), GFR < 60 (HR 2.1; 95%CI 1.2 - 3.7) and active endocarditis (HR 6.4; 95%CI 2.7 - 15.4) as variables associated with reduced long-term survival. The cumulative incidence of re-operation after mitral valve replacement was 11.3 ± 3.2% at 5-year and for repair 16.2 ± 7.5% at 5-year. The cumulative incidence of more than moderate recurrent regurgitation after mitral valve repair was 25.4 ± 9.0% at 3-year. Minimally invasive access in reoperative mitral valve surgery in the current study showed similar 30-day mortality and stroke rate compared to repeat sternotomy results reported in literature.

摘要

在许多中心,微创二尖瓣手术(MIMVS)已成为二尖瓣病变的标准治疗方法。前外侧小切口开胸入路在再次手术中具有优势,可避免再次开胸相关的风险。本研究旨在分析该技术的安全性。对2008年至2019年间接受再次手术MIMVS的所有患者进行回顾性研究。主要终点为30天主要并发症和死亡率;次要结局为长期生存率、再次手术率和中度以上复发反流率。146例患者接受了再次手术MIMVS,平均年龄为68±8岁。30天主要并发症和死亡率的综合结果为29.5%。30天死亡率为6.2%,卒中率为3.4%。在1年随访时,整个队列的生存率为89.7±2.5%,5年时为71.6±4.3%,8年时为50.9±5.9%。Cox回归分析显示,左心室功能降低(HR 2.8;95%CI 1.5 - 5.0)、肾小球滤过率<60(HR 2.1;95%CI 1.2 - 3.7)和活动性心内膜炎(HR 6.4;95%CI 2.7 - 15.4)是与长期生存率降低相关的变量。二尖瓣置换术后再次手术的累积发生率在5年时为11.3±3.2%,修复术后为16.2±7.5%。二尖瓣修复术后中度以上复发反流的累积发生率在3年时为25.4±9.0%。在本研究中,再次手术二尖瓣手术的微创入路与文献报道的再次开胸结果相比,30天死亡率和卒中率相似。

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