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分子印迹聚合物作为一种选择性吸附剂在生物样品中的法医应用综述。

Molecularly imprinted polymers as a selective sorbent for forensic applications in biological samples-a review.

机构信息

Laboratório de Petroleômica e Forense, Universidade Federal do Espírito Santo (UFES), Avenida Fernando Ferrari, 514, Goiabeiras, Vitória, ES, CEP: 29075-910, Brazil.

Departamento de Ciências Naturais, Universidade Federal de São João del-Rei, Campus Dom Bosco, Praça Dom Helvécio 74, Fábricas, São João del-Rei, Minas Gerais, 36301-160, Brazil.

出版信息

Anal Bioanal Chem. 2021 Oct;413(24):6013-6036. doi: 10.1007/s00216-021-03596-x. Epub 2021 Aug 24.

Abstract

Molecularly imprinted polymers (MIP) consist of a molecular recognition technology with applicability in different areas, including forensic chemistry. Among the forensic applications, the use of MIP in biological fluid analysis has gained prominence. Biological fluids are complex samples that generally require a pre-treatment to eliminate interfering agents to improve the results of the analyses. In this review, we address the development of this molecular imprinting technology over the years, highlighting the forensic applications of molecularly imprinted polymers in biological sample preparation for analysis of stimulant drugs such as cocaine, amphetamines, and nicotine.

摘要

分子印迹聚合物(MIP)是一种分子识别技术,具有广泛的应用领域,包括法医学。在法医学应用中,MIP 在生物体液分析中的应用尤为突出。生物体液是复杂的样本,通常需要预处理以消除干扰剂,从而提高分析结果的准确性。本文综述了多年来该分子印迹技术的发展,重点介绍了分子印迹聚合物在生物样品制备中的法医学应用,用于分析可卡因、苯丙胺和尼古丁等兴奋剂药物。

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