Kwan Wing Sum, Roy Vellaisamy A L, Yu Kwan Ngok
Department of Physics, City University of Hong Kong, Tat Chee Ave., Kowloon Tong, Kowloon, Hong Kong, China.
Department of Materials Science and Engineering, City University of Hong Kong, Tat Chee Ave., Kowloon Tong, Kowloon, Hong Kong, China.
Toxics. 2021 Aug 21;9(8):193. doi: 10.3390/toxics9080193.
Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in consumer products. People are continuously exposed to DEHP through ingestion, inhalation and dermal absorption. From epidemiological studies, DEHP has been shown to associate with various adverse health effects, such as reproductive abnormalities and metabolic diseases. Health concerns have been raised regarding DEHP exposures; therefore, relevant risk assessment has become necessary through toxicological testing of DEHP. In the past 10 years, an increasing number of DEHP toxicity studies have been using zebrafish embryos as an in vivo model due to their high fecundity, rapid embryonic development as well as optical transparency, which have now been established as an alternative of the more conventional rodent model. The aim of the present paper is to review the effects of acute (from embryo stage to ≤1 week) and chronic (from embryo stage to >1 week) DEHP exposures on zebrafish, which start from the embryonic stage, and to analyze acute and potential long-term effects induced by acute exposure and effects induced by chronic exposure of DEHP upon subjecting to exposures, starting from the embryonic stage to different developmental stages, with a view to facilitate risk assessments on DEHP exposures.
邻苯二甲酸二（2-乙基己基）酯（DEHP）作为增塑剂在消费品中被广泛使用。人们通过摄入、吸入和皮肤吸收不断接触DEHP。从流行病学研究来看，DEHP已被证明与各种不良健康影响有关，如生殖异常和代谢疾病。人们对DEHP暴露引发了健康担忧；因此，有必要通过对DEHP进行毒理学测试来进行相关风险评估。在过去十年中，越来越多的DEHP毒性研究使用斑马鱼胚胎作为体内模型，因为它们繁殖力高、胚胎发育迅速且具有光学透明性，现在已被确立为更传统啮齿动物模型的替代模型。本文的目的是综述从胚胎期开始的急性（从胚胎期到≤1周）和慢性（从胚胎期到>1周）DEHP暴露对斑马鱼的影响，并分析从胚胎期开始到不同发育阶段暴露于DEHP时，急性暴露引起的急性和潜在长期影响以及慢性暴露引起的影响，以便于对DEHP暴露进行风险评估。
