WPI-Nano Life Science Institute, Kanazawa University, Kanazawa 920-1192, Japan.
Graduate School of Frontier Science Initiative, Kanazawa University, Kanazawa 920-1192, Japan.
Cells. 2021 Aug 18;10(8):2123. doi: 10.3390/cells10082123.
Nuclear pore complexes (NPCs) at the surface of nuclear membranes play a critical role in regulating the transport of both small molecules and macromolecules between the cell nucleus and cytoplasm via their multilayered spiderweb-like central channel. During mitosis, nuclear envelope breakdown leads to the rapid disintegration of NPCs, allowing some NPC proteins to play crucial roles in the kinetochore structure, spindle bipolarity, and centrosome homeostasis. The aberrant functioning of nucleoporins (Nups) and NPCs has been associated with autoimmune diseases, viral infections, neurological diseases, cardiomyopathies, and cancers, especially leukemia. This Special Issue highlights several new contributions to the understanding of NPC proteostasis.
核孔复合体（NPCs）位于核膜表面，通过其多层蛛网状中央通道，在调节小分子和大分子在细胞核和细胞质之间的运输方面发挥着关键作用。在有丝分裂过程中，核膜破裂导致 NPCs 的迅速解体，使一些 NPC 蛋白在动粒结构、纺锤体两极和中心体稳态中发挥关键作用。核孔蛋白（Nups）和 NPCs 的异常功能与自身免疫性疾病、病毒感染、神经退行性疾病、心肌病和癌症（尤其是白血病）有关。本期特刊重点介绍了对 NPC 蛋白稳态理解的一些新贡献。
