玛卡硫代海因，一种新型的含硫代六氢咪唑并[1,5-a]吡啶部分的硫代海因，来自玛卡（Walp.）。
Macathiohydantoin , a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca ( Walp.).
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
University of the Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Molecules. 2021 Aug 14;26(16):4934. doi: 10.3390/molecules26164934.
Five new thiohydantoin derivatives (-) were isolated from the rhizomes of Walp. NMR (H and C NMR, H-H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound was the first example of thiohydantoins with thioxohexahydroimidazo [1,5-a] pyridine moiety. Additionally, compounds and possess rare disulfide bonds. Except for compound , all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (-)- exhibited moderate neuroprotective activity (cell viability: 68.63%, 20 μM) compared to the positive control desipramine (DIM) (cell viability: 88.49%, 10 μM).
从 Walp. 的根茎中分离得到了五个新的硫代海因衍生物（-）。采用 NMR（H 和 C NMR、H-H COSY、HSQC 和 HMBC）、HRESIMS 和 ECD 对新化合物的结构进行了阐明。值得注意的是，化合物的结构是具有硫代六氢咪唑并[1,5-a]吡啶部分的硫代海因的首例实例。此外，化合物和具有罕见的二硫键。除了化合物，所有分离出的化合物均评估了对皮质酮（CORT）刺激的 PC12 细胞损伤的神经保护活性。其中，与阳性对照去甲丙咪嗪（DIM）（细胞活力：88.49%，10 μM）相比，化合物（-）表现出中等的神经保护活性（细胞活力：68.63%，20 μM）。
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