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烷基溶血磷脂在肿瘤细胞膜中的积累会影响膜流动性和肿瘤细胞侵袭。

Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion.

作者信息

van Blitterswijk W J, Hilkmann H, Storme G A

机构信息

Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam.

出版信息

Lipids. 1987 Nov;22(11):820-3. doi: 10.1007/BF02535537.

DOI:10.1007/BF02535537
PMID:3444372
Abstract

Tumor cells grown in the presence of 1-O-alkyl-2-O-methylglycero-3-phosphocholine (AMG-PC) accumulated this ether lipid in their membranes. Depending on the cell type and the dose of the compound, up to 17% of the total phospholipids of the purified plasma membranes consisted of authentic AMG-PC. Extensive incorporation of the agent resulted in a decrease in plasma membrane fluidity and inhibition of tumor cell invasiveness in embryonic chick heart fragments. The extent of AMG-PC incorporation and fluidity change was not strictly correlated with the degree to which tumor cell invasion was inhibited.

摘要

在1-O-烷基-2-O-甲基甘油-3-磷酸胆碱（AMG-PC）存在的情况下培养的肿瘤细胞，会在其细胞膜中积累这种醚脂。根据细胞类型和该化合物的剂量，纯化质膜中高达17%的总磷脂由纯的AMG-PC组成。该试剂的大量掺入导致质膜流动性降低，并抑制了肿瘤细胞在胚胎鸡心脏组织块中的侵袭性。AMG-PC的掺入程度和流动性变化与肿瘤细胞侵袭受到抑制的程度并不严格相关。

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