Department of Bromatology, Poznan University of Medical Sciences, 42 Marcelińska Street, 60-354 Poznań, Poland.
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, 27/33 Szpitalna Street, 60-572 Poznań, Poland.
Nutrients. 2021 Jul 25;13(8):2542. doi: 10.3390/nu13082542.
The inappropriate concentration of copper (Cu) and zinc (Zn) in formulae for infants can lead to abnormal micronutrient intake and adverse health outcomes. This study aimed to determine the concentration of Cu and Zn in different formulae and evaluate the Cu/Zn ratio. Besides, the daily intake (DI) of both micronutrients was estimated. Cu and Zn concentration in 103 formulae for infants, available in the Polish market, were assessed using atomic absorption spectrometry. The estimated DI was calculated from the average energy requirements for the 0-6 months aged infants. The microelement content of formulae was mostly in good agreement with that declared by the manufacturer (5-10% variations compared to the labeled values). The Cu/Zn ratio ranged from 1:8 to 1:25. The estimated DI of Cu was in the range of 0.14-1.11 mg/day. Six (6.7%) of the formulae did not meet the recommended range of Cu intake, especially during the first month of life and in the case of formulae for special medical purposes. The estimated DI of Zn varied from 2.27-11.25 mg/day. In most cases, the concentration of Cu and Zn in infant formulae was within the recommended range. It would be advisable to consider monitoring the DI of Cu and reconsider the Cu content in formulae for infants in proportion to its expected consumption.
婴儿配方中铜（Cu）和锌（Zn）浓度不当，可能导致微量营养素摄入异常和健康不良后果。本研究旨在确定不同配方中 Cu 和 Zn 的浓度，并评估 Cu/Zn 比值。此外，还估算了这两种微量营养素的每日摄入量（DI）。使用原子吸收光谱法评估了波兰市场上 103 种婴儿配方中 Cu 和 Zn 的浓度。从 0-6 个月龄婴儿的平均能量需求计算了估计的 DI。配方中微量元素的含量与制造商申报的含量大多相符（与标签值相比有 5-10%的变化）。Cu/Zn 比值范围为 1:8 至 1:25。Cu 的估计 DI 范围为 0.14-1.11 毫克/天。有 6 种（6.7%）配方不符合推荐的 Cu 摄入量范围，尤其是在生命的第一个月和特殊医疗用途配方中。Zn 的估计 DI 从 2.27-11.25 毫克/天不等。在大多数情况下，婴儿配方中 Cu 和 Zn 的浓度在推荐范围内。建议考虑监测 Cu 的 DI，并根据预期的消耗量重新考虑婴儿配方中 Cu 的含量。
