癌症中长链非编码 RNA 的治疗靶向。
Therapeutic Targeting of Long Non-Coding RNAs in Cancer.
机构信息
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; These authors contributed equally.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
出版信息
Trends Mol Med. 2018 Mar;24(3):257-277. doi: 10.1016/j.molmed.2018.01.001. Epub 2018 Feb 12.
Abstract
Long non-coding RNAs (lncRNAs) represent a significant population of the human transcriptome. Many lncRNAs exhibit cell- and/or tissue/tumor-specific expression, making them excellent candidates for therapeutic applications. In this review we discuss examples of lncRNAs that demonstrate the diversity of their function in various cancer types. We also discuss recent advances in nucleic acid drug development with a focus on oligonucleotide-based therapies as a novel approach to inhibit tumor progression. The increased success rates of nucleic acid therapeutics provide an outstanding opportunity to explore lncRNAs as viable therapeutic targets to combat various aspects of cancer progression.
摘要
长非编码 RNA（lncRNA）是人类转录组的重要组成部分。许多 lncRNA 表现出细胞和/或组织/肿瘤特异性表达，使它们成为治疗应用的优秀候选者。在这篇综述中，我们讨论了一些 lncRNA 的例子，这些例子展示了它们在各种癌症类型中的功能多样性。我们还讨论了核酸药物开发的最新进展，重点是基于寡核苷酸的治疗方法，作为抑制肿瘤进展的一种新方法。核酸疗法成功率的提高为探索 lncRNA 作为可行的治疗靶点提供了极好的机会，以对抗癌症进展的各个方面。
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