School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Adv Healthc Mater. 2021 Oct;10(20):e2100996. doi: 10.1002/adhm.202100996. Epub 2021 Aug 27.
Traditional drug delivery routes possess various disadvantages which make them unsuitable for certain population groups, or indeed unsuitable for drugs with certain physicochemical properties. As a result, a variety of alternative drug delivery routes have been explored in recent decades, including transdermal drug delivery. One of the most promising novel transdermal drug delivery technologies is a microarray patch (MAP), which can bypass the outermost skin barrier and deliver drugs directly into the viable epidermis and dermis. Unlike traditional MAPs which release loaded cargo simultaneously upon insertion into the skin, stimuli responsive MAPs based on biological stimuli are able to precisely release the drug in response to the need for additional doses. Thus, smart MAPs that are only responsive to certain external stimuli are highly desirable, as they provide safer and more efficient drug delivery. In addition to drug delivery, they can also be used for biological monitoring, which further expands their applications.
传统的药物输送途径存在各种缺点，使其不适合某些人群，或者确实不适合某些具有特定物理化学性质的药物。因此，近几十年来，人们探索了各种替代药物输送途径，包括透皮药物输送。最有前途的新型透皮药物输送技术之一是微阵列贴片（MAP），它可以绕过最外层的皮肤屏障，将药物直接输送到有活力的表皮和真皮中。与传统的 MAP 不同，传统的 MAP 在插入皮肤时会同时释放加载的货物，而基于生物刺激的响应性 MAP 能够根据需要额外剂量精确释放药物。因此，只对某些外部刺激有反应的智能 MAP 是非常理想的，因为它们提供了更安全、更有效的药物输送。除了药物输送，它们还可用于生物监测，这进一步扩展了它们的应用。
