Das Arundhati, Sinha Tanvi, Shyamal Sharmishtha, Panda Amaresh Chandra
Institute of Life Sciences, Nalco Square, Bhubaneswar 751023, India.
School of Biotechnology, KIIT University, Bhubaneswar 751024, India.
Noncoding RNA. 2021 Aug 4;7(3):48. doi: 10.3390/ncrna7030048.
Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA-protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered circRNAs. RBPs are a large family of proteins known to play a critical role in gene expression by modulating RNA splicing, nuclear export, mRNA stability, localization, and translation. However, the interaction of RBPs with circRNAs and their implications on circRNA biogenesis and function has been emerging in the last few years. Recent studies suggest that circRNA interaction with target proteins modulates the interaction of the protein with downstream target mRNAs or proteins. This review outlines the emerging mechanisms of circRNA-protein interactions and their functional role in cell physiology.
环状RNA（circRNAs）正逐渐成为各种生物过程中基因表达的新型调节因子。CircRNAs通过与细胞调节因子（如微小RNA和RNA结合蛋白（RBPs））相互作用来调节基因表达，进而调控下游基因表达。高通量RNA-蛋白质相互作用数据的积累揭示了RBPs与编码和非编码RNA的相互作用，包括最近发现的circRNAs。RBPs是一大类蛋白质，已知它们通过调节RNA剪接、核输出、mRNA稳定性、定位和翻译在基因表达中发挥关键作用。然而，RBPs与circRNAs的相互作用及其对circRNA生物合成和功能的影响在过去几年中才逐渐显现。最近的研究表明，circRNA与靶蛋白的相互作用会调节该蛋白与下游靶mRNA或蛋白的相互作用。本综述概述了circRNA-蛋白质相互作用的新兴机制及其在细胞生理学中的功能作用。
