基于分子印迹聚合物的仿生传感器在实际样本中生物分析物的检测：综述。

Department of Physical Chemistry, Faculty for Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria.

Sensors (Basel). 2021 Aug 18;21(16):5550. doi: 10.3390/s21165550.

Molecularly imprinted polymers (MIPs) come with the promise to be highly versatile, useful artificial receptors for sensing a wide variety of analytes. Despite a very large body of literature on imprinting, the number of papers addressing real-life biological samples and analytes is somewhat limited. Furthermore, the topic of MIP-based sensor design is still, rather, in the research stage and lacks wide-spread commercialization. This review summarizes recent advances of MIP-based sensors targeting biological species. It covers systems that are potentially interesting in medical applications/diagnostics, in detecting illicit substances, environmental analysis, and in the quality control of food. The main emphasis is placed on work that demonstrates application in real-life matrices, including those that are diluted in a reasonable manner. Hence, it does not restrict itself to the transducer type, but focusses on both materials and analytical tasks.

分子印迹聚合物（MIPs）有望成为多功能、有用的人工受体，用于检测各种分析物。尽管关于印迹的文献很多，但涉及实际生物样本和分析物的论文数量还是有些有限。此外，基于 MIP 的传感器设计的主题仍然处于研究阶段，尚未广泛商业化。本文综述了基于 MIP 的生物传感器的最新进展。它涵盖了在医学应用/诊断、检测违禁物质、环境分析和食品质量控制方面具有潜在应用价值的系统。主要重点是展示在实际基质中应用的工作，包括以合理方式稀释的基质。因此，它不仅限于换能器类型，而是专注于材料和分析任务。