Mustafa Yasemin L, Keirouz Antonios, Leese Hannah S
Materials for Health Lab, Department of Chemical Engineering, University of Bath, Bath, BA2 7AY, UK.
Centre for Biosensors, Bioelectronics and Biodevices (C3Bio), University of Bath, Bath, BA2 7AY, UK.
J Mater Chem B. 2022 Sep 28;10(37):7418-7449. doi: 10.1039/d2tb00703g.
Bio-applied molecularly imprinted polymers (MIPs) are biomimetic materials with tailor-made synthetic recognition sites, mimicking biological counterparts known for their sensitive and selective analyte detection. MIPs, specifically designed for biomarker analysis within biofluids, have the potential to significantly aid patient diagnostics at the point-of-care, enabling self-health monitoring and management. Recent research in this field, facilitated by the hybridisation of materials science and biology, has developed and utilised a variety of different polymerisation synthesis methods tailored to the bio-application of MIPs. This review evaluates the principles of molecular imprinting for disease diagnostics, including recent progress in integrated MIP-sensor technologies for high-affinity analyte detection in complex biofluids from serum and saliva to cerebrospinal fluid, sweat, urine, nasopharyngeal fluid, and tears. The work highlights the state-of-the-art in the progression of MIP-sensor technologies' translation into commercially available sensors and their potential contribution to disease detection systems in healthcare settings.
生物应用分子印迹聚合物（MIPs）是具有定制合成识别位点的仿生材料，模仿以灵敏且选择性地检测分析物而闻名的生物对应物。专门设计用于生物流体中生物标志物分析的MIPs，有潜力在护理点显著辅助患者诊断，实现自我健康监测与管理。材料科学与生物学的结合推动了该领域的最新研究，已开发并利用了多种针对MIPs生物应用量身定制的不同聚合合成方法。本综述评估了用于疾病诊断的分子印迹原理，包括集成MIP传感器技术在从血清、唾液到脑脊液、汗液、尿液、鼻咽液和泪液等复杂生物流体中高亲和力检测分析物方面的最新进展。这项工作突出了MIP传感器技术转化为商用传感器的进展现状及其对医疗保健环境中疾病检测系统的潜在贡献。
