Kromer Christian, Wellmann Phoebe, Siemer Ralf, Klein Selina, Mohr Johannes, Pinter Andreas, Wilsmann-Theis Dagmar, Mössner Rotraut
Department of Dermatology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Faculty of Medicine, University of Göttingen, 37073 Göttingen, Germany.
Vaccines (Basel). 2021 Aug 1;9(8):843. doi: 10.3390/vaccines9080843.
The risk of developing severe complications from an influenza virus infection is increased in patients with chronic inflammatory diseases such as psoriasis (PsO) and atopic dermatitis (AD). However, low influenza vaccination rates have been reported. The aim of this study was to determine vaccination rates in PsO compared to AD patients and explore patient perceptions of vaccination. A multicenter cross-sectional study was performed in 327 and 98 adult patients with PsO and AD, respectively. Data on vaccination, patient and disease characteristics, comorbidity, and patient perceptions was collected with a questionnaire. Medical records and vaccination certificates were reviewed. A total of 49.8% of PsO and 32.7% of AD patients were vaccinated at some point, while in season 2018/2019, 30.9% and 13.3% received an influenza vaccination, respectively. There were 96.6% and 77.6% of PsO and AD patients who had an indication for influenza vaccination due to age, immunosuppressive therapy, comorbidity, occupation, and/or pregnancy. Multivariate regression analysis revealed higher age ( < 0.001) and a history of bronchitis ( = 0.023) as significant predictors of influenza vaccination in PsO patients. Considering that most patients had an indication for influenza vaccination, the rate of vaccinated patients was inadequately low.
患有银屑病(PsO)和特应性皮炎(AD)等慢性炎症性疾病的患者感染流感病毒后发生严重并发症的风险会增加。然而,据报道流感疫苗接种率较低。本研究的目的是确定银屑病患者与特应性皮炎患者的疫苗接种率,并探讨患者对疫苗接种的看法。分别对327例和98例成年银屑病患者和特应性皮炎患者进行了一项多中心横断面研究。通过问卷调查收集了疫苗接种、患者及疾病特征、合并症和患者看法等方面的数据。查阅了病历和疫苗接种证书。共有49.8%的银屑病患者和32.7%的特应性皮炎患者曾在某个时间接种过疫苗,而在2018/2019季节,分别有30.9%和13.3%的患者接种了流感疫苗。由于年龄、免疫抑制治疗、合并症、职业和/或怀孕,分别有96.6%的银屑病患者和77.6%的特应性皮炎患者有接种流感疫苗的指征。多因素回归分析显示,年龄较大(<0.001)和有支气管炎病史(=0.023)是银屑病患者接种流感疫苗的重要预测因素。考虑到大多数患者有接种流感疫苗的指征,接种疫苗的患者比例低得令人无法接受。