Jia Yi-Na, Sun Jing, Chen Lei, Xue Yan
Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Ningde Road 16, Qingdao, 266071, Shandong, China.
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao, China.
Biol Trace Elem Res. 2022 Jun;200(6):2651-2659. doi: 10.1007/s12011-021-02897-7. Epub 2021 Aug 27.
The existing evidence on the relationships of serum zinc, copper, and zinc/copper ratio with sleep duration is limited and conflicting. The present cross-sectional study aimed to investigate these associations in general adults by utilizing data from the 2011-2016 National Health and Nutrition Examination Survey. The concentrations of zinc and copper were measured in serum samples. Sleep duration (self-reported usual sleep duration) was categorized as < 7 h/night (short sleep duration), 7-8 h/night (optimal sleep duration), and > 8 h/night (long sleep duration). Multinomial logistic regression models and restricted cubic splines were constructed to examine the associations of serum zinc, copper, and zinc/copper ratio with sleep duration. A total of 5067 adults were included. After multivariate adjustment, compared with the optimal sleep duration group, the odds ratios (ORs) (95% confidence intervals, CIs) in the long sleep duration group for the highest versus lowest quartile of serum zinc concentration and zinc/copper ratio were 0.61 (0.39-0.96) and 0.58 (0.38-0.89), respectively. Furthermore, among males, the OR (95% CI) of long sleep duration for the highest versus lowest quartile of serum copper concentration was 2.23 (1.15-4.32). Finally, the dose-response trends suggested that participants with optimal sleep duration had the highest serum zinc concentration and zinc/copper ratio and a slightly lower serum copper concentration. No significant association was found between serum zinc, copper concentrations and the zinc/copper ratio and short sleep duration. In conclusion, serum zinc and zinc/copper ratio were inversely related to long sleep duration in adults, while serum copper was positively associated with long sleep duration in males.
关于血清锌、铜以及锌/铜比值与睡眠时间之间关系的现有证据有限且相互矛盾。本横断面研究旨在利用2011 - 2016年国家健康与营养检查调查的数据，调查一般成年人中的这些关联。在血清样本中测量锌和铜的浓度。睡眠时间（自我报告的通常睡眠时间）分为<7小时/晚（短睡眠时间）、7 - 8小时/晚（最佳睡眠时间）和>8小时/晚（长睡眠时间）。构建多项逻辑回归模型和受限立方样条来检验血清锌、铜以及锌/铜比值与睡眠时间的关联。共纳入5067名成年人。经过多变量调整后，与最佳睡眠时间组相比，长睡眠时间组中血清锌浓度和锌/铜比值最高四分位数与最低四分位数的比值比（OR）（95%置信区间，CI）分别为0.61（0.39 - 0.96）和0.58（0.38 - 0.89）。此外，在男性中，血清铜浓度最高四分位数与最低四分位数相比，长睡眠时间的OR（95%CI）为2.23（1.15 - 4.32）。最后，剂量反应趋势表明，具有最佳睡眠时间的参与者血清锌浓度和锌/铜比值最高，血清铜浓度略低。未发现血清锌、铜浓度以及锌/铜比值与短睡眠时间之间存在显著关联。总之，血清锌和锌/铜比值与成年人的长睡眠时间呈负相关，而血清铜与男性的长睡眠时间呈正相关。
