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肺腺癌和肾乳头细胞癌中新型 lncRNA-miRNA-mRNA 竞争内源性 RNA 调控网络。

A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma.

机构信息

Department of Urology, Chinese People's Liberation Army General Hospital/PLA Medical School, Beijing, China.

Department of Urology, Chinese People's Liberation Army No.92493 Hospital, Huludao, China.

出版信息

Thorac Cancer. 2021 Oct;12(19):2526-2536. doi: 10.1111/1759-7714.14129. Epub 2021 Aug 28.

DOI:10.1111/1759-7714.14129
PMID:34453499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8487820/
Abstract

BACKGROUND

GPRIN1 may be a novel tumor regulator, but its role and mechanism in tumors are still unclear.

METHODS

First, a pan-cancer correlation analysis was conducted on the expression and prognosis of GPRIN1 based on the data downloaded from The Cancer Genome Atlas (TCGA) database. Second, the Starbase database was used to predict the upstream miRNAs and lncRNAs of GPRIN1, and the expression analysis, survival analysis, and correlation analysis were performed to screen the microRNA (miRNAs)/long non-coding RNAs (lncRNAs) that had a correlation with kidney renal papillary cell carcinoma (KIRP) or lung adenocarcinoma (LUAD). Third, the CIBERSORT algorithm was employed to calculate the proportion of various types of immune cells, and then the R packages were used for evaluating the relation between GPRIN1 expression and tumor immune cell infiltration as well as between GPRIN1 and the immune cell biomarker. Finally, the correlation analysis was made on GPRIN1 and immune checkpoints (CD274, CTLA4, and PDCD1).

RESULTS

The pan-cancer analysis suggested that GPRIN1 was up-expressed in KIRP and LUAD, and it correlated with poor prognosis. LINC00894/MMP25-AS1/SNHG1/LINC02298/MIR193BHG-miR-140-3p was likely to be the most promising upstream regulation pathway of GPRIN1. Upexpression of LINC00894/MMP25-AS1/SNHG1/LINC02298/MIR193BHG and downexpression of miR-140-3p were found relevant with poor outcomes of KIRP and LUAD. GPRIN1 expression was significantly correlated with tumor immune cell infiltration, immune cell biomarkers, and immune checkpoints.

CONCLUSIONS

The competitive endogenous (ceRNA) of miR-140-3p-GPRIN1 axis and its upstream lncRNAs are closely related to KIRP and LUAD, and might affect the prognosis and therapeutic effect of KIRP and LUAD.

摘要

背景

GPRIN1 可能是一种新型的肿瘤调节剂，但它在肿瘤中的作用和机制尚不清楚。

方法

首先，根据从癌症基因组图谱（TCGA）数据库下载的数据，对 GPRIN1 的表达和预后进行泛癌相关性分析。其次，利用 Starbase 数据库预测 GPRIN1 的上游微小 RNA（miRNA）和长链非编码 RNA（lncRNA），并进行表达分析、生存分析和相关性分析，筛选与肾透明细胞癌（KIRP）或肺腺癌（LUAD）相关的 miRNA/lncRNA。第三，采用 CIBERSORT 算法计算各种类型免疫细胞的比例，然后使用 R 包评估 GPRIN1 表达与肿瘤免疫细胞浸润的关系以及 GPRIN1 与免疫细胞标志物的关系。最后，对 GPRIN1 与免疫检查点（CD274、CTLA4 和 PDCD1）进行相关性分析。

结果

泛癌分析表明，GPRIN1 在 KIRP 和 LUAD 中呈高表达，与预后不良相关。LINC00894/MMP25-AS1/SNHG1/LINC02298/MIR193BHG-miR-140-3p 可能是 GPRIN1 最有前途的上游调控途径。LINC00894/MMP25-AS1/SNHG1/LINC02298/MIR193BHG 的高表达和 miR-140-3p 的低表达与 KIRP 和 LUAD 的不良预后相关。GPRIN1 的表达与肿瘤免疫细胞浸润、免疫细胞标志物和免疫检查点显著相关。

结论

miR-140-3p-GPRIN1 轴及其上游 lncRNA 的 ceRNA 与 KIRP 和 LUAD 密切相关，可能影响 KIRP 和 LUAD 的预后和治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/5ae024db52c5/TCA-12-2526-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/0ed2560e11bc/TCA-12-2526-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/ebacb89fa999/TCA-12-2526-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/1bb44eab31ec/TCA-12-2526-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/6b9074516af6/TCA-12-2526-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/bf77314c3004/TCA-12-2526-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/5ae024db52c5/TCA-12-2526-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/0ed2560e11bc/TCA-12-2526-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/ebacb89fa999/TCA-12-2526-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/1bb44eab31ec/TCA-12-2526-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/6b9074516af6/TCA-12-2526-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/bf77314c3004/TCA-12-2526-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f61/8487820/5ae024db52c5/TCA-12-2526-g004.jpg

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