Shandong Provincial Key Laboratory of Animal Resistant, School of Life Sciences, Shandong Normal University, Jinan 250014, China.
Int J Mol Sci. 2020 Feb 20;21(4):1456. doi: 10.3390/ijms21041456.
Programmed Cell Death (PCD) is considered to be a pathological form of cell death when mediated by an intracellular program and it balances cell death with survival of normal cells. Pyroptosis, a type of PCD, is induced by the inflammatory caspase cleavage of gasdermin D (GSDMD) and apoptotic caspase cleavage of gasdermin E (GSDME). This review aims to summarize the latest molecular mechanisms about pyroptosis mediated by pore-forming GSDMD and GSDME proteins that permeabilize plasma and mitochondrial membrane activating pyroptosis and apoptosis. We also discuss the potentiality of pyroptosis as a therapeutic target in human diseases. Blockade of pyroptosis by compounds can treat inflammatory disease and pyroptosis activation contributes to cancer therapy.
程序性细胞死亡（PCD）被认为是一种由细胞内程序介导的病理性细胞死亡形式，它平衡了细胞死亡和正常细胞的存活。细胞焦亡是一种 PCD 类型，由炎症性半胱天冬酶切割 Gasdermin D（GSDMD）和凋亡半胱天冬酶切割 Gasdermin E（GSDME）诱导。本综述旨在总结由形成孔的 GSDMD 和 GSDME 蛋白介导的细胞焦亡的最新分子机制，这些蛋白可使质膜和线粒体膜通透性增加，从而激活细胞焦亡和细胞凋亡。我们还讨论了细胞焦亡作为人类疾病治疗靶点的潜力。通过化合物抑制细胞焦亡可以治疗炎症性疾病，而细胞焦亡的激活有助于癌症治疗。
