• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

How necessary are animal models for modern drug discovery?

作者信息

Singh Vijay K, Seed Thomas M

机构信息

Division of Radioprotectants, Department of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.

出版信息

Expert Opin Drug Discov. 2021 Dec;16(12):1391-1397. doi: 10.1080/17460441.2021.1972255. Epub 2021 Sep 3.

DOI:10.1080/17460441.2021.1972255
PMID:34455867
Abstract
摘要

相似文献

1
How necessary are animal models for modern drug discovery?动物模型对现代药物研发有多必要？
Expert Opin Drug Discov. 2021 Dec;16(12):1391-1397. doi: 10.1080/17460441.2021.1972255. Epub 2021 Sep 3.
2
Cell and small animal models for phenotypic drug discovery.用于表型药物发现的细胞和小动物模型。
Drug Des Devel Ther. 2017 Jun 28;11:1957-1967. doi: 10.2147/DDDT.S129447. eCollection 2017.
3
Removing obstacles in neuroscience drug discovery: the future path for animal models.消除神经科学药物研发中的障碍：动物模型的未来之路。
Neuropsychopharmacology. 2009 Jan;34(1):74-89. doi: 10.1038/npp.2008.173. Epub 2008 Oct 1.
4
Zebrafish: a complete animal model for in vivo drug discovery and development.斑马鱼：用于体内药物发现与开发的完整动物模型。
Curr Drug Metab. 2009 Feb;10(2):116-24. doi: 10.2174/138920009787522197.
5
[The Usefulness of Silkworms as a Model Animal for Evaluating the Effectiveness of Medicine and Food].[家蚕作为评估药食功效的模式动物的用途]
Yakugaku Zasshi. 2017;137(5):551-562. doi: 10.1248/yakushi.16-00249.
6
A New Approach to Optimising the Use of Animal Models in Drug Discovery through Big Data Sharing.通过大数据共享优化药物研发中动物模型使用的新方法。
Altern Lab Anim. 2015 Nov;43(5):P55-8. doi: 10.1177/026119291504300517.
7
Improving productivity of modern-day drug discovery.提高现代药物发现的生产力。
Expert Opin Drug Discov. 2014 Feb;9(2):115-8. doi: 10.1517/17460441.2014.870150. Epub 2013 Dec 12.
8
Minipigs as models in drug discovery.小型猪作为药物研发中的模型。
Expert Opin Drug Discov. 2016 Dec;11(12):1131-1134. doi: 10.1080/17460441.2016.1223039. Epub 2016 Aug 22.
9
Are animal models a necessity for acute radiation syndrome drug discovery?动物模型对于急性放射综合征药物研发来说是必需的吗？
Expert Opin Drug Discov. 2019 Jun;14(6):511-515. doi: 10.1080/17460441.2019.1591364. Epub 2019 Mar 14.
10
Have animal models of disease helped or hindered the drug discovery process?疾病的动物模型是否有助于或阻碍了药物发现过程？
Ann N Y Acad Sci. 2011 Dec;1245:1-2. doi: 10.1111/j.1749-6632.2011.06375.x.

引用本文的文献

1
Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders.关于使用人类诱导多能干细胞进行神经精神疾病神经药理学研究的建议、指南和最佳实践。
Neurosci Appl. 2023 Mar 20;2:101125. doi: 10.1016/j.nsa.2023.101125. eCollection 2023.
2
Dose-dependent myopia-suppressing effect of 4-phenlybutyric acid eye drops in a mouse myopia model under masked condition.在遮蔽条件下，4-苯基丁酸滴眼液在小鼠近视模型中的剂量依赖性近视抑制作用。
BMC Ophthalmol. 2025 Jul 1;25(1):383. doi: 10.1186/s12886-025-04213-6.
3
From precision interventions to precision health.
从精准干预到精准健康。
Nat Commun. 2025 May 30;16(1):5024. doi: 10.1038/s41467-025-60395-z.
4
Study of acute lethality, teratogenesis, and metabolomic changes of N-(2'-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) on Artemia franciscana.N-(2'-羟基苯基)-2-丙基戊酰胺（HO-AAVPA）对卤虫急性致死性、致畸性及代谢组学变化的研究
Sci Rep. 2025 May 28;15(1):18644. doi: 10.1038/s41598-025-03325-9.
5
The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory Animals.在涉及实验动物的临床前研究中优化3R（替代、减少、优化）框架的3C（细胞培养、计算机模拟、临床试验）解决方案。
ACS Pharmacol Transl Sci. 2025 Apr 9;8(5):1188-1204. doi: 10.1021/acsptsci.4c00661. eCollection 2025 May 9.
6
The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery.小鼠模型在抗疟药物发现中确定体内药代动力学、安全性和疗效方面的重要性。
Pharmaceuticals (Basel). 2025 Mar 18;18(3):424. doi: 10.3390/ph18030424.
7
Microfluidic platforms for monitoring cardiomyocyte electromechanical activity.用于监测心肌细胞机电活动的微流控平台。
Microsyst Nanoeng. 2025 Jan 9;11(1):4. doi: 10.1038/s41378-024-00751-z.
8
Mechanism of streptozotocin to induce cardiac fibrosis through TNFa and Bcl2 pathways in and study.链脲佐菌素通过 TNFa 和 Bcl2 途径诱导 和 研究中心脏纤维化的机制。
Open Vet J. 2024 Sep;14(9):2287-2293. doi: 10.5455/OVJ.2024.v14.i9.17. Epub 2024 Sep 30.
9
Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications.环磷酸鸟苷-磷酸腺苷合成酶-干扰素基因刺激因子通路在糖尿病及其并发症中的作用
World J Diabetes. 2024 Oct 15;15(10):2041-2057. doi: 10.4239/wjd.v15.i10.2041.
10
The Pivotal Role of Preclinical Animal Models in Anti-Cancer Drug Discovery and Personalized Cancer Therapy Strategies.临床前动物模型在抗癌药物研发及个性化癌症治疗策略中的关键作用
Pharmaceuticals (Basel). 2024 Aug 9;17(8):1048. doi: 10.3390/ph17081048.