Nguyen Van Dang, Duong Van Nghia, Le Van Quang, Ngo Thanh Tung, Ta Van To
Department of Oncology, Hanoi Medical University, Hanoi, Vietnam.
Department of Head and Neck Radiation Oncology, Vietnam National Cancer Hospital, Hanoi, Vietnam.
J Blood Med. 2021 Aug 21;12:769-774. doi: 10.2147/JBM.S326165. eCollection 2021.
Primary central nervous system (CNS) lymphoma is an uncommon non-Hodgkin disease limited to the CNS, and most cases are diffuse large B-cell lymphomas. Other pathologies, including lymphoplasmacytic lymphoma (LPL), are exceedingly rare and poorly understood. The clinical presentation of primary CNS LPL is diverse. It depends on the original site and the tumor's extension. There is currently no consensus on a treatment strategy for this uncommon manifestation. To our knowledge, no previously published case was successfully treated with radiation therapy alone.
We present here a case of primary CNS LPL. A 46-year-old, previously healthy woman was presented with a worsening headache and lower extremity numbness. Multifocal enhanced masses were detected in an MRI with biopsy results consistent with LPL. A complete staging workup was performed with no evidence of systemic disease. The patient received external-beam radiotherapy alone and had a complete remission. After 2 years of follow-up, she remains disease-free.
Radiation alone is a promising treatment option for primary CNS lymphoplasmacytic lymphoma.
原发性中枢神经系统（CNS）淋巴瘤是一种局限于中枢神经系统的罕见非霍奇金病，大多数病例为弥漫性大B细胞淋巴瘤。其他病理类型，包括淋巴浆细胞淋巴瘤（LPL），极为罕见且了解甚少。原发性中枢神经系统LPL的临床表现多样。它取决于原发部位和肿瘤的扩展情况。目前对于这种罕见表现的治疗策略尚无共识。据我们所知，之前发表的病例中尚无仅通过放射治疗成功治愈的。
我们在此呈现一例原发性中枢神经系统LPL病例。一名46岁、既往健康的女性出现头痛加重和下肢麻木症状。在MRI检查中发现多灶性强化肿块，活检结果与LPL一致。进行了全面的分期检查，未发现全身疾病的证据。该患者仅接受了外照射放疗，实现了完全缓解。经过2年的随访，她仍无疾病复发。
单纯放疗是原发性中枢神经系统淋巴浆细胞淋巴瘤一种有前景的治疗选择。
