Virology Research Center, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Laboratory of Virology, Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Front Cell Infect Microbiol. 2021 Aug 12;11:710551. doi: 10.3389/fcimb.2021.710551. eCollection 2021.
This manuscript is an up-to-date review of experimentally validated linear and continuous epitopes identified from arbovirus members of the genus. We summarized 153 immunoreactive peptides from the Dengue virus, Zika virus, Japanese encephalitis virus, West Nile virus, and tick-borne encephalitis virus described in studies published from 1989 to 2020. We included peptides from structural (envelope, capsid, and pre-membrane) and nonstructural (Ns1-5) viral proteins that demonstrated relevant immunoreactivity with antibodies from naturally infected or vaccinated humans. We included peptides that demonstrated relevant reactivity features, such as indicators of disease severity related to immunological or immunopathological outcomes, differential or group diagnostic markers, immunotherapy candidates, and potential for vaccine formulation. The majority of immunoreactive peptides were described for DENV probably due to its long-lasting impact on human health and the lack of efficient vaccines and therapeutic methods. Immune landscape data regarding linear immunoreactive and continuous flavivirus peptides are still scarce, and a complete and more detailed map remains to be elucidated. Therefore, this review provides valuable data for those investigating the antibody response against flavivirus infection.
这篇手稿是对属中虫媒病毒成员鉴定出的实验验证的线性和连续表位的最新综述。我们总结了 1989 年至 2020 年期间发表的研究中从登革热病毒、寨卡病毒、日本脑炎病毒、西尼罗河病毒和蜱传脑炎病毒中描述的 153 个免疫反应性肽。我们包括了具有结构（包膜、衣壳和前膜）和非结构（NS1-5）病毒蛋白的肽，这些肽与来自自然感染或接种疫苗的人类的抗体表现出相关的免疫反应性。我们包括了具有相关反应特征的肽，例如与免疫或免疫病理学结果相关的疾病严重程度指标、差异或组诊断标志物、免疫治疗候选物以及疫苗制剂的潜力。大多数免疫反应性肽是针对 DENV 描述的，可能是由于其对人类健康的持久影响，以及缺乏有效的疫苗和治疗方法。关于线性免疫反应性和连续黄病毒肽的免疫景观数据仍然很少，完整且更详细的图谱仍有待阐明。因此，这篇综述为那些研究针对黄病毒感染的抗体反应的人提供了有价值的数据。
