Lefranc Florence
Department of Neurosurgery, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
Front Cell Dev Biol. 2021 Aug 12;9:618961. doi: 10.3389/fcell.2021.618961. eCollection 2021.
Among the most biologically, thus clinically, aggressive primary brain tumors are found malignant gliomas. Despite recent advances in adjuvant therapies, which include targeted and immunotherapies, after surgery and radio/chemotherapy, the tumor is recurrent and always lethal. Malignant gliomas also contain a pool of initiating stem cells that are highly invasive and resistant to conventional treatment. Ion channels and transporters are markedly involved in cancer cell biology, including glioma cell biology. Transient receptor potential (TRP) ion channels are calcium-permeable channels implicated in Ca changes in multiple cellular compartments by modulating the driving force for Ca entry. Recent scientific reports have shown that these channels contribute to the increase in glioblastoma aggressiveness, with glioblastoma representing the ultimate level of glioma malignancy. The current review focuses on each type of TRP ion channel potentially involved in malignant glioma cell death, with the ultimate goal of identifying new therapeutic targets to clinically combat malignant gliomas. It thus appears that cannabidiol targeting the TRPV2 type could be such a potential target.
在生物学上，因而临床上具有最强侵袭性的原发性脑肿瘤是恶性胶质瘤。尽管在辅助治疗方面取得了最新进展，包括靶向治疗和免疫治疗，但在手术及放化疗后，肿瘤仍会复发且总是致命的。恶性胶质瘤还包含一群起始干细胞，这些干细胞具有高度侵袭性且对传统治疗有抗性。离子通道和转运体显著参与癌细胞生物学过程，包括胶质瘤细胞生物学过程。瞬时受体电位（TRP）离子通道是钙通透性通道，通过调节钙进入的驱动力参与多个细胞区室的钙变化。最近的科学报告表明，这些通道促成了胶质母细胞瘤侵袭性的增加，胶质母细胞瘤代表了胶质瘤恶性程度的最终阶段。本综述聚焦于可能参与恶性胶质瘤细胞死亡的每种TRP离子通道类型，最终目标是识别出临床上对抗恶性胶质瘤的新治疗靶点。因此，靶向TRPV2型的大麻二酚似乎可能是这样一个潜在靶点。
