Mahanty Sarmistha, Setty Subba Rao Gangi
Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, India.
Front Cell Dev Biol. 2021 Aug 12;9:701950. doi: 10.3389/fcell.2021.701950. eCollection 2021.
Epidermal lamellar bodies (eLBs) are secretory organelles that carry a wide variety of secretory cargo required for skin homeostasis. eLBs belong to the class of lysosome-related organelles (LROs), which are cell-type-specific organelles that perform diverse functions. The formation of eLBs is thought to be related to that of other LROs, which are formed either through the gradual maturation of Golgi/endosomal precursors or by the conversion of conventional lysosomes. Current evidence suggests that eLB biogenesis presumably initiate from -Golgi network and receive cargo from endosomes, and also acquire lysosome characteristics during maturation. These multistep biogenesis processes are frequently disrupted in human skin disorders. However, many gaps remain in our understanding of eLB biogenesis and their relationship to skin diseases. Here, we describe our current understanding on eLB biogenesis with a focus on cargo transport to this LRO and highlight key areas where future research is needed.
表皮板层小体（eLBs）是分泌性细胞器，携带皮肤稳态所需的多种分泌性货物。eLBs属于溶酶体相关细胞器（LROs）类别，LROs是执行多种功能的细胞类型特异性细胞器。eLBs的形成被认为与其他LROs的形成有关，其他LROs要么通过高尔基体/内体前体的逐渐成熟形成，要么通过传统溶酶体的转化形成。目前的证据表明，eLB生物发生可能始于高尔基体网络并从内体接收货物，并且在成熟过程中还获得溶酶体特征。这些多步骤生物发生过程在人类皮肤疾病中经常受到干扰。然而，我们对eLB生物发生及其与皮肤疾病的关系的理解仍存在许多空白。在这里，我们描述了我们目前对eLB生物发生的理解，重点是货物向这种LRO的运输，并强调了未来研究需要关注的关键领域。
