German Center for Neurodegenerative Diseases (DZNE), site Rostock/Greifswald, Greifswald, Germany.
Department of General Business Administration and Health Care Management, University of Greifswald, Greifswald, Germany.
J Alzheimers Dis. 2021;83(4):1775-1787. doi: 10.3233/JAD-210439.
Low-value care (LvC) is defined as care unlikely to provide a benefit to the patient regarding the patient's preferences, potential harms, costs, or available alternatives. Avoiding LvC and promoting recommended evidence-based treatments, referred to as high-value care (HvC), could improve patient-reported outcomes for people living with dementia (PwD).
This study aims to determine the prevalence of LvC and HvC in dementia and the associations of LvC and HvC with patients' quality of life and hospitalization.
The analysis was based on data of the DelpHi trial and included 516 PwD. Dementia-specific guidelines, the "Choosing Wisely" campaign and the PRISCUS list were used to indicate LvC and HvC treatments, resulting in 347 LvC and HvC related recommendations. Of these, 77 recommendations (51 for LvC, 26 for HvC) were measured within the DelpHi-trial and finally used for this analysis. The association of LvC and HvC treatments with PwD health-related quality of life (HRQoL) and hospitalization was assessed using multiple regression models.
LvC was highly prevalent in PwD (31%). PwD receiving LvC had a significantly lower quality of life (b = -0.07; 95% CI -0.14 - -0.01) and were significantly more likely to be hospitalized (OR = 2.06; 95% CI 1.26-3.39). Different HvC treatments were associated with both positive and negative changes in HRQoL.
LvC could cause adverse outcomes and should be identified as early as possible and tried to be replaced. Future research should examine innovative models of care or treatment pathways supporting the identification and replacement of LvC in dementia.
低价值医疗(LvC)被定义为在患者偏好、潜在危害、成本或可用替代方案方面不太可能为患者提供益处的医疗。避免低价值医疗并推广推荐的基于证据的治疗方法,即高价值医疗(HvC),可以改善痴呆患者的报告结局。
本研究旨在确定痴呆症中低价值和高价值医疗的流行程度,以及低价值和高价值医疗与患者生活质量和住院的关联。
该分析基于 DelpHi 试验的数据,包括 516 名痴呆症患者。使用特定于痴呆症的指南、“明智选择”运动和 PRISCUS 清单来表示低价值和高价值医疗的治疗方法,由此产生了 347 项低价值和高价值相关建议。其中,77 项建议(51 项用于低价值,26 项用于高价值)在 DelpHi 试验中进行了测量,最终用于本分析。使用多元回归模型评估低价值和高价值医疗与痴呆症患者健康相关生活质量(HRQoL)和住院的关联。
痴呆症患者中低价值医疗的发生率很高(31%)。接受低价值医疗的痴呆症患者的生活质量显著较低(b=-0.07;95%CI-0.14 至-0.01),且更有可能住院(OR=2.06;95%CI 1.26 至 3.39)。不同的高价值医疗治疗方法与 HRQoL 的积极和消极变化均相关。
低价值医疗可能导致不良结局,应尽早识别并尝试替换。未来的研究应检验支持痴呆症中识别和替换低价值医疗的创新护理模式或治疗途径。