Jacobsson M, Kälebo P, Tjellström A, Turesson I
Department of Sahlgrenska Sjukhuset, University of Gothenburg, Sweden.
Acta Oncol. 1987;26(6):463-5. doi: 10.3109/02841868709113719.
Adult rabbits were irradiated to one proximal tibial metaphysis while the contralateral tibia served as a control. Each animal was thus its own control. Single doses of 15, 25 and 40 Gy 60Co were used. The follow-up time was 11 to 22 weeks after irradiation. A histochemical method, recording diaphorase (NADH2 and NADPH2) activity in osteocytes, was employed. This method is regarded as superior to conventional histology. No evidence of osteocyte death was found even after 22 weeks following 40 Gy irradiation. This is interpreted as an indication that the osteocytes, which are end stage cells, are relatively radioresistant.
对成年兔子的一侧胫骨近端干骺端进行照射，而对侧胫骨作为对照。因此，每只动物自身即为对照。使用了15、25和40 Gy的60Co单剂量照射。照射后随访时间为11至22周。采用了一种组织化学方法，记录骨细胞中的黄递酶（NADH2和NADPH2）活性。该方法被认为优于传统组织学。即使在40 Gy照射后22周，也未发现骨细胞死亡的证据。这被解释为表明作为终末阶段细胞的骨细胞具有相对的放射抗性。
