Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.
J Clin Lab Anal. 2021 Oct;35(10):e23981. doi: 10.1002/jcla.23981. Epub 2021 Aug 30.
Retinoblastoma is the most common primary intraocular malignancy in children less than 4 years. Retinoblastoma (RB) contains about 3%-5% of all childhood cancers. Recent studies demonstrated that interacting between RB tumor suppressor and oncoproteins of DNA tumor viruses such as human papillomavirus (HPV). The objective of the current systematic review study was to present conducted studies in the field of HPV infection and its possible role in retinoblastoma.
For this systematic review, all relevant original research studies were assessed by searching in electronic databases include PubMed, Embase, Scopus, Google Scholar, and Web of Science by using relevant keywords. The study was designed based on the PRISMA criteria. All publications with English literature and original researches are considered for screening.
Conducted search results lead to 4070 studies. The title and abstract screening lead to 11 studies. Data extraction was performed on 8 included studies. The prevalence of the HPV was ranged from 0 to 69%, and HPV genotype 16 and 18 were the most detected types. The most used method for the detection of the viruses was PCR, and the most assessed sample was formalin-fixed, paraffin-embedded tissue blocks.
The association between HPV and retinoblastoma is still inconsistent. The prevalence of the HPV in RB was ranged from 0 to 69%, which indicates a wide range and highlights the importance of further investigation for more accurate statistical of HPV prevalence in RB. Thus, further worldwide studies of larger sample sizes of cohorts should be investigated to clarify this uncertainty.
视网膜母细胞瘤是 4 岁以下儿童中最常见的原发性眼内恶性肿瘤。视网膜母细胞瘤（RB）约占所有儿童癌症的 3%-5%。最近的研究表明，RB 肿瘤抑制因子与 HPV 等 DNA 肿瘤病毒的癌蛋白之间存在相互作用。本系统评价研究的目的是介绍 HPV 感染及其在视网膜母细胞瘤中可能作用的已发表研究。
为了进行这项系统评价，通过使用相关关键词在电子数据库 PubMed、Embase、Scopus、Google Scholar 和 Web of Science 中搜索，评估了所有相关的原始研究。该研究是基于 PRISMA 标准设计的。所有具有英文文献和原始研究的出版物都被视为筛选对象。
进行的搜索结果导致了 4070 项研究。标题和摘要筛选导致了 11 项研究。对 8 项纳入研究进行了数据提取。HPV 的流行率范围从 0 到 69%，HPV 基因型 16 和 18 是最常检测到的类型。用于检测病毒的最常用方法是 PCR，最常评估的样本是福尔马林固定、石蜡包埋的组织块。
HPV 与视网膜母细胞瘤之间的关联仍然不一致。HPV 在 RB 中的流行率范围从 0 到 69%，这表明范围很广，突出了进一步调查以更准确地统计 RB 中 HPV 流行率的重要性。因此，应该进行进一步的、全球性的、更大样本量的队列研究，以澄清这种不确定性。
