Neuroscience Institute, New York University School of Medicine, New York, United States.
Departments of Neurology, Neuroscience & Physiology, and Radiology, New York University School of Medicine, New York, United States.
Elife. 2021 Aug 31;10:e68265. doi: 10.7554/eLife.68265.
Arousal levels perpetually rise and fall spontaneously. How markers of arousal-pupil size and frequency content of brain activity-relate to each other and influence behavior in humans is poorly understood. We simultaneously monitored magnetoencephalography and pupil in healthy volunteers at rest and during a visual perceptual decision-making task. Spontaneously varying pupil size correlates with power of brain activity in most frequency bands across large-scale resting state cortical networks. Pupil size recorded at prestimulus baseline correlates with subsequent shifts in detection bias () and sensitivity ('). When dissociated from pupil-linked state, prestimulus spectral power of resting state networks still predicts perceptual behavior. Fast spontaneous pupil constriction and dilation correlate with large-scale brain activity as well but not perceptual behavior. Our results illuminate the relation between central and peripheral arousal markers and their respective roles in human perceptual decision-making.
觉醒水平会自发地持续上升和下降。在人类中，觉醒的标志物——瞳孔大小和大脑活动的频率内容——如何相互关联并影响行为，这一点了解甚少。我们在健康志愿者休息和进行视觉感知决策任务时，同时监测脑磁图和瞳孔。在静息状态的大尺度皮质网络中，自发变化的瞳孔大小与大多数频率带的大脑活动功率相关。在刺激前基线记录的瞳孔大小与随后的检测偏差（）和敏感性（'）的变化相关。当与与瞳孔相关的状态分离时，静息状态网络的刺激前频谱功率仍然可以预测感知行为。快速的自发瞳孔收缩和扩张也与大尺度大脑活动相关，但与感知行为无关。我们的结果阐明了中枢和外周觉醒标志物之间的关系，以及它们在人类感知决策中的各自作用。
