Department of Family Medicine, Konya Numune Hospital, Konya, Turkey.
J Clin Lab Anal. 2021 Oct;35(10):e23983. doi: 10.1002/jcla.23983. Epub 2021 Aug 31.
The coronavirus pandemic, an infection (coronavirus disease 2019-COVID-19), caused by severe acute respiratory disease coronavirus 2 (SARS-CoV-2), continues to have a strong influence worldwide. Although smoking is a major known risk factor for respiratory infectious disease, the effects of smoking on COVID-19 are unclear. In this study, we aimed to evaluate the relationship between smoking and important hematologic (lymphocyte count, neutrophil count, platelet count, neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR]), inflammatory, and biochemical biomarkers in the prognosis of hospitalized patients with COVID-19.
In a COVID-19 pandemic hospital between June and August 2020, 200 adult patients aged over 18 years were hospitalized with COVID-19 inflammatory and hematologic biomarkers at their first admission and smoking data were selected for this study.
The rate of smokers was much higher among men (91.5%) than in women (8.5%) (p = 0.001). Neutrophil counts were evaluated and was significantly higher in current smokers (p < 0.001) and ex-smokers (p = 0.001), and NLR (p = 0.008) and ferritin (p = 0.004) levels were higher than in never smokers. The saturation of patients had a negative significant linear correlation of NLR, PLR, and pack years of smoking. Compared with never smokers, current smokers had higher neutrophil counts (OR = 0.828 [0.750-0.915]; p = 0.041), NLR values (OR = 0.948 [0.910-0.987]; p = 0.009), and CRP levels (OR = 0.994 [0.990-0.999]; p = 0.019).
Serum neutrophil, NLR, and ferritin levels, which are widely used in determining the prognosis of COVID-19, were found higher in current smokers/ex-smokers. These results support the view that a poor prognosis of COVID-19 is associated with smoking.
由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的冠状病毒病 2019（COVID-19）感染（即冠状病毒病）继续在全球范围内产生强烈影响。虽然吸烟是呼吸道传染病的主要已知危险因素，但吸烟对 COVID-19 的影响尚不清楚。在这项研究中，我们旨在评估吸烟与住院 COVID-19 患者重要的血液学（淋巴细胞计数、中性粒细胞计数、血小板计数、中性粒细胞-淋巴细胞比值[NLR]、血小板-淋巴细胞比值[PLR]）、炎症和生化生物标志物之间的关系在预后中的作用。
在 2020 年 6 月至 8 月的 COVID-19 大流行医院期间，我们选择了 200 名年龄在 18 岁以上的成年住院 COVID-19 炎症和血液学生物标志物患者，并对其首次入院时的吸烟数据进行了选择。
男性（91.5%）的吸烟者比例明显高于女性（8.5%）（p=0.001）。中性粒细胞计数较高，且当前吸烟者（p<0.001）和前吸烟者（p=0.001）的 NLR（p=0.008）和铁蛋白（p=0.004）水平较高。患者的饱和度与 NLR、PLR 和吸烟包年数呈负显著线性相关。与从不吸烟者相比，当前吸烟者的中性粒细胞计数较高（OR=0.828[0.750-0.915]；p=0.041），NLR 值较高（OR=0.948[0.910-0.987]；p=0.009），C 反应蛋白水平较高（OR=0.994[0.990-0.999]；p=0.019）。
广泛用于确定 COVID-19 预后的血清中性粒细胞、NLR 和铁蛋白水平在当前吸烟者/前吸烟者中较高。这些结果支持 COVID-19 预后不良与吸烟有关的观点。
