School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China.
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China.
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Dec;250:109175. doi: 10.1016/j.cbpc.2021.109175. Epub 2021 Aug 28.
Bisphenol S (BPS) has been gradually used in all kinds of productions. Our previous study has demonstrated that BPS increases the obesogenic effects of a high-glucose diet through regulating lipid metabolism in Caenorhabditis elegans (C. elegans). Whether the effects pass on to the next generations remains uncovered. In the present study, C. elegans was selected as the model organism to investigate the effects of BPS on lipid metabolism in multiple generations. Oil Red O staining and triglyceride assays showed that multi-generational exposure to BPS in C. elegans significantly increased the fat accumulation in wild type worms, while not in the daf-16 gene-deficient worms. In addition, BPS affected the expressions of fat-7 and acs-2 in four generations of C. elegans. Furthermore, BPS promotes fat storage in C. elegans of multiple generations by the daf-16/nhr-49-mediated signaling pathway.
双酚 S（BPS）已逐渐应用于各种产品中。我们之前的研究表明，BPS 通过调节秀丽隐杆线虫（C. elegans）的脂质代谢增加了高糖饮食的致肥胖作用。但其是否会传递给下一代尚未可知。在本研究中，选择秀丽隐杆线虫作为模型生物来研究 BPS 对其多代脂质代谢的影响。油红 O 染色和甘油三酯测定表明，BPS 在秀丽隐杆线虫中的多代暴露显著增加了野生型蠕虫的脂肪积累，而在 daf-16 基因缺失型蠕虫中则没有。此外，BPS 还影响了 C. elegans 中 fat-7 和 acs-2 的表达。此外，BPS 通过 daf-16/nhr-49 介导的信号通路促进了 C. elegans 的多代脂肪储存。
